FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002161457> ?p ?o ?g. }

• W2002161457 endingPage "313" @default.
• W2002161457 startingPage "305" @default.
• W2002161457 abstract "The demonstration that zinc-finger transcriptional repressors can control E-cadherin expression in epithelial cells has provided a new avenue of research in the field of epithelial-mesenchymal transition (EMT). One of these zinc-finger molecules is the transcription factor Snail, which controls gastrulation and neural crest EMT in different species. Additionally, Snail is involved in the development of malignant melanoma where a dramatic change in E-cadherin expression is an important early step for melanoma progression. For this study, a human cancer cDNA array was used which includes genes involved in cancer development and progression. Using the array we compared the gene expression pattern of the melanoma cell line Mel Im with a Mel Im cell clone stable transfected with antisense (as) SNAIL cDNA. We validated the significant differences of the expression of genes on mRNA level. Primarily, we observed changes in the expression of genes involved in EMT. Quantitative real-time polymerase chain reaction showed a down-regulation of MMP-2, EMMPRIN, SPARC, TIMP-1, t-PA, RhoA and Notch4 expression and a re-induction of E-cadherin expression in the as Snail cell clones. Furthermore, we measured the expression of integrin β3, NM23b and RhoB. Additionally, we investigated whether the selected genes are influenced only through Snail or if E-cadherin can influence the expression of these genes. In summary, all examined genes which are influenced through Snail have a regulatory function in EMT processes as does Snail itself. The Snail target gene E-cadherin has no regulatory function with respect to the selected genes." @default.
• W2002161457 created "2016-06-24" @default.
• W2002161457 creator A5003470722 @default.
• W2002161457 creator A5015596280 @default.
• W2002161457 creator A5022275810 @default.
• W2002161457 creator A5074073161 @default.
• W2002161457 date "2005-08-01" @default.
• W2002161457 modified "2023-10-17" @default.
• W2002161457 title "Snail-regulated genes in malignant melanoma" @default.
• W2002161457 cites W1508097413 @default.
• W2002161457 cites W1965940794 @default.
• W2002161457 cites W1970140424 @default.
• W2002161457 cites W1976075428 @default.
• W2002161457 cites W1977346307 @default.
• W2002161457 cites W1985721503 @default.
• W2002161457 cites W1993977050 @default.
• W2002161457 cites W1994242450 @default.
• W2002161457 cites W2001541126 @default.
• W2002161457 cites W2001626727 @default.
• W2002161457 cites W2002194537 @default.
• W2002161457 cites W2006417453 @default.
• W2002161457 cites W2013082155 @default.
• W2002161457 cites W2013480667 @default.
• W2002161457 cites W2019731805 @default.
• W2002161457 cites W2027284511 @default.
• W2002161457 cites W2037520415 @default.
• W2002161457 cites W2039298921 @default.
• W2002161457 cites W2039913958 @default.
• W2002161457 cites W2042470484 @default.
• W2002161457 cites W2043670884 @default.
• W2002161457 cites W2043797012 @default.
• W2002161457 cites W2055007848 @default.
• W2002161457 cites W2065832539 @default.
• W2002161457 cites W2072400772 @default.
• W2002161457 cites W2077792958 @default.
• W2002161457 cites W2087367170 @default.
• W2002161457 cites W2096791952 @default.
• W2002161457 cites W2111099066 @default.
• W2002161457 cites W2112341071 @default.
• W2002161457 cites W2129122766 @default.
• W2002161457 cites W2141629829 @default.
• W2002161457 cites W2146445411 @default.
• W2002161457 cites W2152893516 @default.
• W2002161457 cites W2155837153 @default.
• W2002161457 cites W2165901622 @default.
• W2002161457 cites W2183610572 @default.
• W2002161457 cites W2345927070 @default.
• W2002161457 cites W70565427 @default.
• W2002161457 cites W88296184 @default.
• W2002161457 doi "https://doi.org/10.1097/00008390-200508000-00012" @default.
• W2002161457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16034310" @default.
• W2002161457 hasPublicationYear "2005" @default.
• W2002161457 type Work @default.
• W2002161457 sameAs 2002161457 @default.
• W2002161457 citedByCount "84" @default.
• W2002161457 countsByYear W20021614572012 @default.
• W2002161457 countsByYear W20021614572013 @default.
• W2002161457 countsByYear W20021614572014 @default.
• W2002161457 countsByYear W20021614572015 @default.
• W2002161457 countsByYear W20021614572016 @default.
• W2002161457 countsByYear W20021614572017 @default.
• W2002161457 countsByYear W20021614572018 @default.
• W2002161457 countsByYear W20021614572020 @default.
• W2002161457 countsByYear W20021614572021 @default.
• W2002161457 countsByYear W20021614572023 @default.
• W2002161457 crossrefType "journal-article" @default.
• W2002161457 hasAuthorship W2002161457A5003470722 @default.
• W2002161457 hasAuthorship W2002161457A5015596280 @default.
• W2002161457 hasAuthorship W2002161457A5022275810 @default.
• W2002161457 hasAuthorship W2002161457A5074073161 @default.
• W2002161457 hasConcept C104317684 @default.
• W2002161457 hasConcept C127561419 @default.
• W2002161457 hasConcept C150194340 @default.
• W2002161457 hasConcept C153911025 @default.
• W2002161457 hasConcept C187882448 @default.
• W2002161457 hasConcept C18903297 @default.
• W2002161457 hasConcept C24284526 @default.
• W2002161457 hasConcept C2777124376 @default.
• W2002161457 hasConcept C2777658100 @default.
• W2002161457 hasConcept C2779965526 @default.
• W2002161457 hasConcept C502942594 @default.
• W2002161457 hasConcept C54355233 @default.
• W2002161457 hasConcept C555283112 @default.
• W2002161457 hasConcept C76419328 @default.
• W2002161457 hasConcept C86339819 @default.
• W2002161457 hasConcept C86803240 @default.
• W2002161457 hasConceptScore W2002161457C104317684 @default.
• W2002161457 hasConceptScore W2002161457C127561419 @default.
• W2002161457 hasConceptScore W2002161457C150194340 @default.
• W2002161457 hasConceptScore W2002161457C153911025 @default.
• W2002161457 hasConceptScore W2002161457C187882448 @default.
• W2002161457 hasConceptScore W2002161457C18903297 @default.
• W2002161457 hasConceptScore W2002161457C24284526 @default.
• W2002161457 hasConceptScore W2002161457C2777124376 @default.
• W2002161457 hasConceptScore W2002161457C2777658100 @default.
• W2002161457 hasConceptScore W2002161457C2779965526 @default.
• W2002161457 hasConceptScore W2002161457C502942594 @default.
• W2002161457 hasConceptScore W2002161457C54355233 @default.

• next