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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002161745> ?p ?o ?g. }

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• W2002161745 abstract "Twenty-four derivatives of erythrocentaurin (ET) were synthesized and evaluated for their anti-HBV activities on HepG 2.2.15 cell line in vitro. Eight compounds 1, 2, 5, 8, 9, 1e, 1k, and 1m increased activity against HBV DNA replication with the SI values higher than 11. In particular, derivatives 1e and 1k exhibited the most potent inhibition on HBV DNA replication with the IC50 values of 0.026 mM (SI>70.8) and 0.045 mM (SI>36.0), respectively. The primary structure-activity relationships (SARs) of ET derivatives were summarized for exploring potent anti-HBV agents." @default.
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• W2002161745 date "2015-04-01" @default.
• W2002161745 modified "2023-10-16" @default.
• W2002161745 title "Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors" @default.
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• W2002161745 doi "https://doi.org/10.1016/j.bmcl.2015.02.009" @default.
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