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- W2002163554 abstract "This chapter highlights zymogen granules (ZGs) of pancreas and the parotid gland. It describes the overall variations of the ZG compartment and the variations of the granule size under a variety of physiological conditions. The chapter also examines the origin and fate of ZGs as observed by cytochemical methods and summarizes the contribution of freeze–fracture techniques to the definition of the ZG membrane architecture. The electrophysiological properties of ZGs and the influence of the cytoskeleton on secretion are discussed. The pancreas and the parotid gland process their macromolecular products by cisternal packaging and exocytosis. The size distribution of the ZGs in the parotid gland cells shows some points of similarity with that observed in the pancreas. During exocytosis the ZG membrane fuses with the luminal plasmalemma, allowing the discharge of granule content. The cytoskeleton controls the movement of ZGs toward the cell apex. The nature of these interactions may be much more complex than a simple ZG alignment in the apical cytoplasm. The life of a ZG starts in the trans-Golgi saccule, in the form of condensing vacuole (CV). Both size and electron opacity of the forming CV are highly variable." @default.
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- W2002163554 date "1954-01-01" @default.
- W2002163554 modified "2023-10-18" @default.
- W2002163554 title "Distributions of chymotrypsinogen, procarboxypeptidase, desoxyribonuclease, and ribonuclease in bovine pancreas" @default.
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- W2002163554 doi "https://doi.org/10.1016/0014-4827(54)90167-6" @default.
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