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- W2002164559 abstract "Abstract An efficient microwave‐assisted synthesis of 8‐hydroxy‐6,7‐dimethoxy‐3‐hydroxymethyl isocoumarin (1), a metabolite of Streptomyces mobaraensis and structural relative of reticulol and cytogenin that possesses potent cyclic nucleotide phosphodiesterase inhibitor activity, is described. 3,4,5‐Trimethoxyhomophthalic acid (2) was condensed with acetoxyacetyl chloride under microwave irradiation and the acid hydrolysis of resulting 6,7,8‐trimethoxy‐3‐acetoxymethylisocoumarin (3) afforded the 6,7,8‐trimethoxy‐3‐hydroxymethylisocoumarin (4). Regioselective demethylation of the latter using magnesium iodide in THF yielded the title compound (1)." @default.
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- W2002164559 date "2007-05-01" @default.
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- W2002164559 title "Microwave‐Assisted Synthesis of cAMP Phosphodiesterase Inhibitor 8‐Hydroxy‐6,7‐dimethoxy‐3‐hydroxymethylisocoumarin" @default.
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- W2002164559 doi "https://doi.org/10.1080/00397910701228778" @default.
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