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- W2002166884 abstract "The human blood platelet membrane glycoprotein Ib (GPIb) functions as a receptor for von Willebrand factor and thrombin. The gene (gpIbα) encoding the GPIb α-chain was cloned from a genomic cosmid library. The promoter region of this gene was characterized by sequencing two BamHI fragments including 2.8 kb of the 5′ flanking region where several Alu repeated elements and purine-rich sequences were found. Possible cis-regulatory elements were identified by comparing the gpIbα gene with established consensus sequences known to function as binding sites for transcription factors. To obtain further information on possible megakaryocyte-specific promoter or enhancer sequences, the gpIbα, promoter region was compared with other genes expressed in platelets that are known so far. The gpIbα gene was found to be located on chromosome 17 in region 17p12-ter, by in situ hybridization." @default.
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- W2002166884 date "1989-12-01" @default.
- W2002166884 modified "2023-10-16" @default.
- W2002166884 title "The 5′ flanking region and chromosomal localization of the gene encoding human platelet membrane glycoprotein Ibα" @default.
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- W2002166884 doi "https://doi.org/10.1016/0378-1119(89)90446-0" @default.
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