Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002168442> ?p ?o ?g. }
- W2002168442 endingPage "865" @default.
- W2002168442 startingPage "855" @default.
- W2002168442 abstract "Synaptic activation of the transcription factor CREB and downstream gene expression usually depend on calcium influx aided by voltage-gated calcium channels. We find that nicotinic signaling, in contrast, activates CREB and gene expression in ciliary ganglion neurons both in culture and in situ only if voltage-gated channels are silent. The nicotinic response requires calcium influx and release from internal stores and acts through CaMK and MAPK pathways to sustain activated CREB. Voltage-gated channels mobilize CaMK to activate CREB initially, but they also enable calcineurin and PP1 to terminate the activation before transcription is affected. L-type voltage-gated channels dominate the outcome and block the effects of nicotinic signaling on transcription. This demonstrates a novel aspect of activity-dependent gene regulation." @default.
- W2002168442 created "2016-06-24" @default.
- W2002168442 creator A5001790127 @default.
- W2002168442 creator A5055814759 @default.
- W2002168442 date "2001-12-01" @default.
- W2002168442 modified "2023-09-26" @default.
- W2002168442 title "Voltage-Gated Channels Block Nicotinic Regulation of CREB Phosphorylation and Gene Expression in Neurons" @default.
- W2002168442 cites W1491836134 @default.
- W2002168442 cites W1553730410 @default.
- W2002168442 cites W1560330290 @default.
- W2002168442 cites W1573261410 @default.
- W2002168442 cites W1585306115 @default.
- W2002168442 cites W1587310874 @default.
- W2002168442 cites W1876165476 @default.
- W2002168442 cites W1887401978 @default.
- W2002168442 cites W1919086687 @default.
- W2002168442 cites W1920124704 @default.
- W2002168442 cites W1974896225 @default.
- W2002168442 cites W1976057396 @default.
- W2002168442 cites W1984323006 @default.
- W2002168442 cites W1998448534 @default.
- W2002168442 cites W2001801891 @default.
- W2002168442 cites W2005744880 @default.
- W2002168442 cites W2011882079 @default.
- W2002168442 cites W2016773845 @default.
- W2002168442 cites W2020634566 @default.
- W2002168442 cites W2022729995 @default.
- W2002168442 cites W2024316065 @default.
- W2002168442 cites W2025247587 @default.
- W2002168442 cites W2028055687 @default.
- W2002168442 cites W2029252387 @default.
- W2002168442 cites W2036109749 @default.
- W2002168442 cites W2036581055 @default.
- W2002168442 cites W2041497541 @default.
- W2002168442 cites W2041958488 @default.
- W2002168442 cites W2049134173 @default.
- W2002168442 cites W2057727146 @default.
- W2002168442 cites W2061675635 @default.
- W2002168442 cites W2069268251 @default.
- W2002168442 cites W2075009214 @default.
- W2002168442 cites W2081406035 @default.
- W2002168442 cites W2094182857 @default.
- W2002168442 cites W2094930349 @default.
- W2002168442 cites W2095535075 @default.
- W2002168442 cites W2111117071 @default.
- W2002168442 cites W2112659765 @default.
- W2002168442 cites W2112681888 @default.
- W2002168442 cites W2119361029 @default.
- W2002168442 cites W2128396585 @default.
- W2002168442 cites W2133850147 @default.
- W2002168442 cites W2145537874 @default.
- W2002168442 cites W2147917606 @default.
- W2002168442 cites W2159424315 @default.
- W2002168442 cites W2169264956 @default.
- W2002168442 cites W2323622483 @default.
- W2002168442 cites W4298025967 @default.
- W2002168442 doi "https://doi.org/10.1016/s0896-6273(01)00516-5" @default.
- W2002168442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11738031" @default.
- W2002168442 hasPublicationYear "2001" @default.
- W2002168442 type Work @default.
- W2002168442 sameAs 2002168442 @default.
- W2002168442 citedByCount "155" @default.
- W2002168442 countsByYear W20021684422012 @default.
- W2002168442 countsByYear W20021684422013 @default.
- W2002168442 countsByYear W20021684422014 @default.
- W2002168442 countsByYear W20021684422015 @default.
- W2002168442 countsByYear W20021684422016 @default.
- W2002168442 countsByYear W20021684422017 @default.
- W2002168442 countsByYear W20021684422018 @default.
- W2002168442 countsByYear W20021684422019 @default.
- W2002168442 countsByYear W20021684422020 @default.
- W2002168442 countsByYear W20021684422021 @default.
- W2002168442 countsByYear W20021684422022 @default.
- W2002168442 countsByYear W20021684422023 @default.
- W2002168442 crossrefType "journal-article" @default.
- W2002168442 hasAuthorship W2002168442A5001790127 @default.
- W2002168442 hasAuthorship W2002168442A5055814759 @default.
- W2002168442 hasBestOaLocation W20021684421 @default.
- W2002168442 hasConcept C104317684 @default.
- W2002168442 hasConcept C11960822 @default.
- W2002168442 hasConcept C150109051 @default.
- W2002168442 hasConcept C150194340 @default.
- W2002168442 hasConcept C1629964 @default.
- W2002168442 hasConcept C169760540 @default.
- W2002168442 hasConcept C170493617 @default.
- W2002168442 hasConcept C178790620 @default.
- W2002168442 hasConcept C185592680 @default.
- W2002168442 hasConcept C18699975 @default.
- W2002168442 hasConcept C188987157 @default.
- W2002168442 hasConcept C2776281502 @default.
- W2002168442 hasConcept C2778565530 @default.
- W2002168442 hasConcept C2779555244 @default.
- W2002168442 hasConcept C519063684 @default.
- W2002168442 hasConcept C54355233 @default.
- W2002168442 hasConcept C86339819 @default.
- W2002168442 hasConcept C86803240 @default.
- W2002168442 hasConcept C94487597 @default.
- W2002168442 hasConcept C95444343 @default.