Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002168522> ?p ?o ?g. }
- W2002168522 endingPage "13" @default.
- W2002168522 startingPage "1" @default.
- W2002168522 abstract "Obese postmenopausal women have an increased risk of breast cancer and are likely to have a worse prognosis than nonobese postmenopausal women. The cessation of ovarian function after menopause results in withdrawal of ovarian sex steroid hormones, estrogen, and progesterone. Accumulating evidence suggests that the withdrawal of estrogen and progesterone causes homeostasis imbalances, including decreases in insulin sensitivity and leptin secretion and changes in glucose and lipid metabolism, resulting in a total reduction in energy expenditure. Together with a decrease in physical activity and consumption of a high fat diet, these factors significantly contribute to obesity in postmenopausal women. Obesity may contribute to breast cancer development through several mechanisms. Obesity causes localized inflammation, an increase in local estrogen production, and changes in cellular metabolism. In addition, obese women have a higher risk of insulin insensitivity, and an increase in insulin and other growth factor secretion. In this review, we describe our current understanding of the molecular actions of estrogen and progesterone and their contributions to cellular metabolism, obesity, inflammation, and postmenopausal breast cancer. We also discuss how modifications of estrogen and progesterone actions might be used as a therapeutic approach for obesity and postmenopausal breast cancer." @default.
- W2002168522 created "2016-06-24" @default.
- W2002168522 creator A5002030977 @default.
- W2002168522 creator A5083881148 @default.
- W2002168522 date "2015-01-01" @default.
- W2002168522 modified "2023-09-23" @default.
- W2002168522 title "The Role of Ovarian Sex Steroids in Metabolic Homeostasis, Obesity, and Postmenopausal Breast Cancer: Molecular Mechanisms and Therapeutic Implications" @default.
- W2002168522 cites W1551632868 @default.
- W2002168522 cites W1569704074 @default.
- W2002168522 cites W16253337 @default.
- W2002168522 cites W1627267625 @default.
- W2002168522 cites W1965507613 @default.
- W2002168522 cites W1966199649 @default.
- W2002168522 cites W1967607481 @default.
- W2002168522 cites W1970050679 @default.
- W2002168522 cites W1970078194 @default.
- W2002168522 cites W1971960644 @default.
- W2002168522 cites W1974196451 @default.
- W2002168522 cites W1975432421 @default.
- W2002168522 cites W1978281808 @default.
- W2002168522 cites W1978454776 @default.
- W2002168522 cites W1980180618 @default.
- W2002168522 cites W1980385764 @default.
- W2002168522 cites W1987417875 @default.
- W2002168522 cites W1990477938 @default.
- W2002168522 cites W1990883896 @default.
- W2002168522 cites W1996592151 @default.
- W2002168522 cites W1996821015 @default.
- W2002168522 cites W1999738495 @default.
- W2002168522 cites W2007317632 @default.
- W2002168522 cites W2010714248 @default.
- W2002168522 cites W2012740498 @default.
- W2002168522 cites W2012863911 @default.
- W2002168522 cites W2015207840 @default.
- W2002168522 cites W2015891324 @default.
- W2002168522 cites W2019933602 @default.
- W2002168522 cites W2021880374 @default.
- W2002168522 cites W2022101765 @default.
- W2002168522 cites W2022965804 @default.
- W2002168522 cites W2023667812 @default.
- W2002168522 cites W2024265396 @default.
- W2002168522 cites W2025078194 @default.
- W2002168522 cites W2025280569 @default.
- W2002168522 cites W2025995094 @default.
- W2002168522 cites W2028574685 @default.
- W2002168522 cites W2028897202 @default.
- W2002168522 cites W2029255902 @default.
- W2002168522 cites W2034825007 @default.
- W2002168522 cites W2037725361 @default.
- W2002168522 cites W2039064011 @default.
- W2002168522 cites W2040025789 @default.
- W2002168522 cites W2041314232 @default.
- W2002168522 cites W2041695109 @default.
- W2002168522 cites W2041830601 @default.
- W2002168522 cites W2044603199 @default.
- W2002168522 cites W2047616905 @default.
- W2002168522 cites W2049965556 @default.
- W2002168522 cites W2051292313 @default.
- W2002168522 cites W2051303794 @default.
- W2002168522 cites W2051512444 @default.
- W2002168522 cites W2051783431 @default.
- W2002168522 cites W2052552833 @default.
- W2002168522 cites W2053127012 @default.
- W2002168522 cites W2057653317 @default.
- W2002168522 cites W2060506834 @default.
- W2002168522 cites W2065531561 @default.
- W2002168522 cites W2065683049 @default.
- W2002168522 cites W2067562513 @default.
- W2002168522 cites W2069409907 @default.
- W2002168522 cites W2071542414 @default.
- W2002168522 cites W2072451938 @default.
- W2002168522 cites W2074143255 @default.
- W2002168522 cites W2077518977 @default.
- W2002168522 cites W2078802143 @default.
- W2002168522 cites W2079184586 @default.
- W2002168522 cites W2079681040 @default.
- W2002168522 cites W2080549540 @default.
- W2002168522 cites W2082521320 @default.
- W2002168522 cites W2084663681 @default.
- W2002168522 cites W2087497728 @default.
- W2002168522 cites W2088203665 @default.
- W2002168522 cites W2088295388 @default.
- W2002168522 cites W2088604185 @default.
- W2002168522 cites W2089044757 @default.
- W2002168522 cites W2092171701 @default.
- W2002168522 cites W2093076064 @default.
- W2002168522 cites W2099687396 @default.
- W2002168522 cites W2103581424 @default.
- W2002168522 cites W2104940203 @default.
- W2002168522 cites W2105365180 @default.
- W2002168522 cites W2109110436 @default.
- W2002168522 cites W2112665865 @default.
- W2002168522 cites W2113137306 @default.
- W2002168522 cites W2113576333 @default.
- W2002168522 cites W2116130431 @default.
- W2002168522 cites W2118278569 @default.
- W2002168522 cites W2119525258 @default.
- W2002168522 cites W2124138867 @default.