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• W2002169560 abstract "Objective: We previously demonstrated that altered zinc homeostasis is an important feature of pediatric sepsis, thus raising the possibility of zinc supplementation as a therapeutic strategy in sepsis. Herein, we tested the hypothesis that prophylactic zinc supplementation would be beneficial in a murine model of peritoneal sepsis. Design: Murine model of sepsis (intraperitoneal fecal-slurry injection). Setting: Basic science research laboratory. Subjects: C57BL/6 male mice. Interventions: Intraperitoneal fecal-slurry injection, with or without zinc supplementation (10 mg/kg of intraperitoneal zinc gluconate for 3 days prior to intraperitoneal fecal-slurry injection). Measurements and Main Results: Survival over 3 days following intraperitoneal fecal-slurry injection, markers of inflammation, bacterial load studies, and immunophenotyping studies. Zinc-supplemented mice demonstrated a significant survival advantage compared to control (nonsupplemented) mice. Zinc-supplemented mice also demonstrated moderate reductions of inflammation and immune activation. The survival advantage primarily correlated with reduced in vivo bacterial load in zinc-supplemented mice, compared to controls. In addition, peritoneal macrophages harvested from zinc-supplemented mice demonstrated a significantly enhanced phagocytosis capacity for Escherichia coli and Staphylococcus aureus, compared to peritoneal macrophages harvested from control mice. Conclusion: Prophylactic zinc supplementation reduces bacterial load and is beneficial in a murine model of peritoneal sepsis." @default.
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• W2002169560 date "2012-09-01" @default.
• W2002169560 modified "2023-10-12" @default.
• W2002169560 title "Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis" @default.
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• W2002169560 doi "https://doi.org/10.1097/pcc.0b013e31824fbd90" @default.
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