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- W2002171465 abstract "The mammalian master clock driving circadian rhythmicity in physiology and behavior resides within the suprachiasmatic nuclei (SCN) of the anterior hypothalamus [1Meijer J.H Rietveld W.J Neurophysiology of the suprachiasmatic circadian pacemaker in rodents.Physiol. Rev. 1989; 69: 671-707Crossref PubMed Scopus (669) Google Scholar, 2Gillette M.U Tischkau S.A Suprachiasmatic nucleus the brain's circadian clock.Recent Prog. Horm. Res. 1999; 54: 33-58PubMed Google Scholar]. Circadian rhythms are generated by a set of clock genes via intertwined negative and positive autoregulatory transcription-translation feedback loops [3Cermakian N Sassone-Corsi P Multilevel regulation of the circadian clock.Nat. Rev. Mol. Cell Biol. 2001; 1: 59-67Crossref Scopus (163) Google Scholar, 4Reppert S.M Weaver D.R Molecular analysis of mammalian circadian rhythms.Annu. Rev. Physiol. 2001; 63: 647-676Crossref PubMed Scopus (1153) Google Scholar, 5Ripperger J.A Schibler U Circadian regulation of gene expression in animals.Curr. Opin. Cell Biol. 2001; 13: 357-362Crossref PubMed Scopus (90) Google Scholar, 6Shearman L.P Sriram S Weaver D.R Maywood E.S Chaves I Zheng B Kume K Lee C.C van der Horst G.T.J Hastings M.H et al.Interacting molecular loops in the mammalian circadian clock.Science. 2000; 288: 1013-1019Crossref PubMed Scopus (1053) Google Scholar]. The Cryptochrome 1 and 2 genes are indispensable for molecular core oscillator function, as evident from the arrhythmic wheel-running behavior and lack of rhythmic clock gene expression in mCry1/mCry2 double-mutant mice in constant darkness [7Van der Horst G.T.J Muijtjens M Kobayashi K Takano R Kanno S Takao M de Wit J Verkerk A Eker A.P van Leenen D et al.Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.Nature. 1999; 398: 627-630Crossref PubMed Scopus (1041) Google Scholar, 8Vitaterna M.H Selby C.P Todo T Niwa H Thompson C Fruechte E.M Hitomi K Thresher R.J Ishikawa T Miyazaki J et al.Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.Proc. Natl. Acad. Sci. USA. 1999; 96: 12114-12119Crossref PubMed Scopus (527) Google Scholar, 9Okamura H Miyake S Sumi Y Yamaguchi S Yasui A Muijtjens M Hoeijmakers J.H.J van der Horst G.T.J Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock.Science. 1999; 286: 2531-2534Crossref PubMed Scopus (326) Google Scholar, 10Yagita S Tamanini F van der Horst G.T.J Okamura H Molecular mechanism of the biological clock in cultured fibroblasts.Science. 2001; 292: 278-281Crossref PubMed Scopus (355) Google Scholar]. In the present study, using real-time multiunit electrode activity recordings in hypothalamic slices, we show that SCN neurons from mCry-deficient mice kept in constant darkness lack circadian oscillations in firing patterns. This proves that cryptochromes, and thus an intact circadian clockwork, are prerequisites for circadian electrical activity in SCN neurons. Interestingly, when mCry-deficient mice were kept in normal light-dark conditions and SCN slices were prepared 2 hr after the beginning of the day, a single noncircadian peak in neuronal activity was detected. This light-induced rise in electrical activity of the SCN may explain why mCry-deficient mice lack the arrhythmic short bouts of wheel-running activity and instead show apparently normal behavior in normal day-night cycles." @default.
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- W2002171465 date "2002-07-01" @default.
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- W2002171465 title "Cryptochrome-Deficient Mice Lack Circadian Electrical Activity in the Suprachiasmatic Nuclei" @default.
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- W2002171465 doi "https://doi.org/10.1016/s0960-9822(02)00923-5" @default.
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