FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002171978> ?p ?o ?g. }

• W2002171978 endingPage "13395" @default.
• W2002171978 startingPage "13390" @default.
• W2002171978 abstract "Caspase-3 knockout mice exhibit thickening of the internal granule cell layer of the cerebellum. Concurrently, it has been shown that intracerebral injection of pituitary adenylate cyclase-activating polypeptide (PACAP) induces a transient increase of the thickness of the cerebellar cortex. In the present study, we have investigated the possible effect of PACAP on caspase activity in cultured cerebellar granule cells from 8-day-old rat. Incubation of granule neurons with PACAP for 24 h promoted cell survival and prevented DNA fragmentation. Exposure of cerebellar granule cells to the specific caspase-3 inhibitor N-benzyloxycarbonyl-Asp-Glu-Val-Asp fluoromethylketone (Z-DEVD-FMK) for 24 h markedly enhanced cell survival and inhibited apoptotic cell death. Time-course studies revealed that PACAP causes a prolonged inhibition of caspase-3 activity without affecting caspase-1. Administration of graded concentrations of PACAP for 3 h induced a dose-dependent inhibition of caspase-3 activity. Incubation of granule cells with both dibutyryl-cAMP (dbcAMP) and phorbol 12-myristate 13-acetate (PMA) mimicked the inhibitory effect of PACAP on caspase-3. Cotreatment of cultured neurons with the protein kinase A inhibitor H89 and the protein kinase C inhibitor chelerythrine abrogated the effect of PACAP on caspase-3 activity. In contrast, the ERK kinase inhibitor U0126 did not affect the action of PACAP on caspase-3 activity. These data demonstrate that PACAP prevents cerebellar granule neurons from apoptotic cell death through a protein kinase A- and protein kinase C-dependent inhibition of caspase-3 activity." @default.
• W2002171978 created "2016-06-24" @default.
• W2002171978 creator A5013133934 @default.
• W2002171978 creator A5015125277 @default.
• W2002171978 creator A5016268593 @default.
• W2002171978 creator A5030108506 @default.
• W2002171978 creator A5031224564 @default.
• W2002171978 creator A5039764958 @default.
• W2002171978 creator A5040108125 @default.
• W2002171978 date "2000-11-21" @default.
• W2002171978 modified "2023-10-06" @default.
• W2002171978 title "The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32" @default.
• W2002171978 cites W1499591683 @default.
• W2002171978 cites W1509047385 @default.
• W2002171978 cites W1513688899 @default.
• W2002171978 cites W1566676785 @default.
• W2002171978 cites W1762207349 @default.
• W2002171978 cites W1845459216 @default.
• W2002171978 cites W1886438078 @default.
• W2002171978 cites W1968537133 @default.
• W2002171978 cites W1972733547 @default.
• W2002171978 cites W1978199801 @default.
• W2002171978 cites W1979154669 @default.
• W2002171978 cites W1986228861 @default.
• W2002171978 cites W1987785848 @default.
• W2002171978 cites W1988821149 @default.
• W2002171978 cites W1993043025 @default.
• W2002171978 cites W1999164276 @default.
• W2002171978 cites W1999444013 @default.
• W2002171978 cites W2000093726 @default.
• W2002171978 cites W2008251162 @default.
• W2002171978 cites W2013362755 @default.
• W2002171978 cites W2014585127 @default.
• W2002171978 cites W2017986123 @default.
• W2002171978 cites W2031273543 @default.
• W2002171978 cites W2037581783 @default.
• W2002171978 cites W2039355845 @default.
• W2002171978 cites W2048952420 @default.
• W2002171978 cites W2049309560 @default.
• W2002171978 cites W2057863962 @default.
• W2002171978 cites W2060865344 @default.
• W2002171978 cites W2062980194 @default.
• W2002171978 cites W2064470441 @default.
• W2002171978 cites W2065265575 @default.
• W2002171978 cites W2068848132 @default.
• W2002171978 cites W2071973579 @default.
• W2002171978 cites W2073179464 @default.
• W2002171978 cites W2074117052 @default.
• W2002171978 cites W2082259697 @default.
• W2002171978 cites W2089822614 @default.
• W2002171978 cites W2096298540 @default.
• W2002171978 cites W2104526708 @default.
• W2002171978 cites W2106630191 @default.
• W2002171978 cites W2111650534 @default.
• W2002171978 cites W2123778528 @default.
• W2002171978 cites W2126144943 @default.
• W2002171978 cites W2136781825 @default.
• W2002171978 cites W2145408804 @default.
• W2002171978 cites W2150302704 @default.
• W2002171978 cites W2151875422 @default.
• W2002171978 cites W2156945415 @default.
• W2002171978 cites W2167275747 @default.
• W2002171978 cites W2169201834 @default.
• W2002171978 cites W2315629023 @default.
• W2002171978 cites W2411421247 @default.
• W2002171978 cites W4234830660 @default.
• W2002171978 cites W86108913 @default.
• W2002171978 doi "https://doi.org/10.1073/pnas.97.24.13390" @default.
• W2002171978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/27234" @default.
• W2002171978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11087878" @default.
• W2002171978 hasPublicationYear "2000" @default.
• W2002171978 type Work @default.
• W2002171978 sameAs 2002171978 @default.
• W2002171978 citedByCount "126" @default.
• W2002171978 countsByYear W20021719782012 @default.
• W2002171978 countsByYear W20021719782013 @default.
• W2002171978 countsByYear W20021719782014 @default.
• W2002171978 countsByYear W20021719782015 @default.
• W2002171978 countsByYear W20021719782016 @default.
• W2002171978 countsByYear W20021719782018 @default.
• W2002171978 countsByYear W20021719782019 @default.
• W2002171978 countsByYear W20021719782020 @default.
• W2002171978 countsByYear W20021719782021 @default.
• W2002171978 countsByYear W20021719782022 @default.
• W2002171978 countsByYear W20021719782023 @default.
• W2002171978 crossrefType "journal-article" @default.
• W2002171978 hasAuthorship W2002171978A5013133934 @default.
• W2002171978 hasAuthorship W2002171978A5015125277 @default.
• W2002171978 hasAuthorship W2002171978A5016268593 @default.
• W2002171978 hasAuthorship W2002171978A5030108506 @default.
• W2002171978 hasAuthorship W2002171978A5031224564 @default.
• W2002171978 hasAuthorship W2002171978A5039764958 @default.
• W2002171978 hasAuthorship W2002171978A5040108125 @default.
• W2002171978 hasBestOaLocation W20021719781 @default.
• W2002171978 hasConcept C118303440 @default.
• W2002171978 hasConcept C12519072 @default.
• W2002171978 hasConcept C126322002 @default.
• W2002171978 hasConcept C134018914 @default.

• next