FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002173586> ?p ?o ?g. }

• W2002173586 endingPage "1698" @default.
• W2002173586 startingPage "1688" @default.
• W2002173586 abstract "BACKGROUND Upper gastrointestinal adenocarcinomas are a common cause of cancer-related deaths. In this study, the authors investigated the prevalence and biological significance of Aurora Kinase A (AURKA) overexpression in upper gastrointestinal adenocarcinomas. METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemical staining on tumor tissue microarrays (TMA) were used to study the expression of AURKA in upper gastrointestinal adenocarcinomas. To investigate the biological and signaling impact of AURKA, the authors used multiple in vitro assays that included 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), TUNEL (terminal deoxynucleotidyl transferase–mediated nick-end labeling), cytochrome C release, flow cytometry, luciferase reporter, and Western blot analysis. RESULTS Frequent overexpression of AURKA transcript in upper gastrointestinal adenocarcinomas was detected compared with normal samples (47%; P = .001). The immunohistochemical analysis of 130 tumors demonstrated moderate-to-strong immunostaining of AURKA in >50% of upper gastrointestinal adenocarcinomas. By using camptothecin as a drug-induced apoptosis in vitro model, the authors demonstrated that the expression of AURKA provided protection against apoptosis to gastrointestinal cancer cells (AGS and RKO) (P = .006) and RIE-1 primary intestinal epithelial cells (P = .001). The AURKA overexpression mediated an increase in phosphorylation of AKTSer473 with an increase in HDM2 level. The shRNA-knockdown of AKT in AURKA-overexpressing cells reversed this effect and showed a significant increase in the p53 protein level, indicating a possible nexus of AURKA/AKT/p53. Indeed, overexpression of AURKA led to a remarkable reduction in the transcription activity of p53, with subsequent reductions in transcript and protein levels of its downstream proapoptotic transcription targets (p21, BAX, NOXA, and PUMA). CONCLUSIONS Study results indicated that AURKA provides potent antiapoptotic properties to gastrointestinal cells by regulating levels of p53 through the AKT/HDM2 axis. Cancer 2008. ©2008 American Cancer Society." @default.
• W2002173586 created "2016-06-24" @default.
• W2002173586 creator A5000074569 @default.
• W2002173586 creator A5001099941 @default.
• W2002173586 creator A5004330175 @default.
• W2002173586 creator A5014370129 @default.
• W2002173586 creator A5032514998 @default.
• W2002173586 creator A5047762415 @default.
• W2002173586 creator A5048600723 @default.
• W2002173586 creator A5054433435 @default.
• W2002173586 creator A5072573472 @default.
• W2002173586 creator A5087368073 @default.
• W2002173586 date "2008-01-01" @default.
• W2002173586 modified "2023-10-18" @default.
• W2002173586 title "Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions" @default.
• W2002173586 cites W1657157395 @default.
• W2002173586 cites W1665081245 @default.
• W2002173586 cites W1954313480 @default.
• W2002173586 cites W1963592300 @default.
• W2002173586 cites W1984507712 @default.
• W2002173586 cites W1989537346 @default.
• W2002173586 cites W1990317973 @default.
• W2002173586 cites W1997845311 @default.
• W2002173586 cites W2003605454 @default.
• W2002173586 cites W2017467516 @default.
• W2002173586 cites W2033923680 @default.
• W2002173586 cites W2040143851 @default.
• W2002173586 cites W2046024015 @default.
• W2002173586 cites W2048121649 @default.
• W2002173586 cites W2056530510 @default.
• W2002173586 cites W2071156666 @default.
• W2002173586 cites W2075000991 @default.
• W2002173586 cites W2080493618 @default.
• W2002173586 cites W2083582547 @default.
• W2002173586 cites W2092817294 @default.
• W2002173586 cites W2092902276 @default.
• W2002173586 cites W2093549611 @default.
• W2002173586 cites W2093877987 @default.
• W2002173586 cites W2104756411 @default.
• W2002173586 cites W2106942695 @default.
• W2002173586 cites W2116635868 @default.
• W2002173586 cites W2135436234 @default.
• W2002173586 cites W2137429755 @default.
• W2002173586 cites W2149814771 @default.
• W2002173586 cites W2158160769 @default.
• W2002173586 cites W2165454946 @default.
• W2002173586 cites W2170710435 @default.
• W2002173586 cites W2338576041 @default.
• W2002173586 cites W4211113621 @default.
• W2002173586 cites W4254765132 @default.
• W2002173586 doi "https://doi.org/10.1002/cncr.23371" @default.
• W2002173586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4030394" @default.
• W2002173586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18311783" @default.
• W2002173586 hasPublicationYear "2008" @default.
• W2002173586 type Work @default.
• W2002173586 sameAs 2002173586 @default.
• W2002173586 citedByCount "100" @default.
• W2002173586 countsByYear W20021735862012 @default.
• W2002173586 countsByYear W20021735862013 @default.
• W2002173586 countsByYear W20021735862014 @default.
• W2002173586 countsByYear W20021735862015 @default.
• W2002173586 countsByYear W20021735862016 @default.
• W2002173586 countsByYear W20021735862017 @default.
• W2002173586 countsByYear W20021735862018 @default.
• W2002173586 countsByYear W20021735862019 @default.
• W2002173586 countsByYear W20021735862020 @default.
• W2002173586 countsByYear W20021735862021 @default.
• W2002173586 countsByYear W20021735862022 @default.
• W2002173586 crossrefType "journal-article" @default.
• W2002173586 hasAuthorship W2002173586A5000074569 @default.
• W2002173586 hasAuthorship W2002173586A5001099941 @default.
• W2002173586 hasAuthorship W2002173586A5004330175 @default.
• W2002173586 hasAuthorship W2002173586A5014370129 @default.
• W2002173586 hasAuthorship W2002173586A5032514998 @default.
• W2002173586 hasAuthorship W2002173586A5047762415 @default.
• W2002173586 hasAuthorship W2002173586A5048600723 @default.
• W2002173586 hasAuthorship W2002173586A5054433435 @default.
• W2002173586 hasAuthorship W2002173586A5072573472 @default.
• W2002173586 hasAuthorship W2002173586A5087368073 @default.
• W2002173586 hasBestOaLocation W20021735861 @default.
• W2002173586 hasConcept C142724271 @default.
• W2002173586 hasConcept C153911025 @default.
• W2002173586 hasConcept C173396325 @default.
• W2002173586 hasConcept C190283241 @default.
• W2002173586 hasConcept C196795494 @default.
• W2002173586 hasConcept C204232928 @default.
• W2002173586 hasConcept C2780808130 @default.
• W2002173586 hasConcept C29537977 @default.
• W2002173586 hasConcept C4224716 @default.
• W2002173586 hasConcept C502942594 @default.
• W2002173586 hasConcept C553184892 @default.
• W2002173586 hasConcept C55493867 @default.
• W2002173586 hasConcept C71924100 @default.
• W2002173586 hasConcept C86803240 @default.
• W2002173586 hasConceptScore W2002173586C142724271 @default.
• W2002173586 hasConceptScore W2002173586C153911025 @default.
• W2002173586 hasConceptScore W2002173586C173396325 @default.
• W2002173586 hasConceptScore W2002173586C190283241 @default.

• next