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- W2002173692 abstract "Abstract Objectives A period of thrombocytopenia is common after stem cell transplantation ( SCT ). To prevent serious bleeding complications, prophylactic platelet transfusions are administered. Previous studies have shown that a rise in immature platelets precedes recovery of platelet count. Our aim was to define a cutoff value for immature platelets predicting thrombopoietic recovery within 2 d. Methods Hematological parameters were measured on the S ysmex XN hemocytometer. We calculated reference change values ( RCV ) for platelets in eight healthy individuals as marker for platelet recovery. To define a cutoff value, we performed ROC analysis using data from 16 autologous SCT patients. Results RCV for platelet concentration was 14.1%. Platelet recovery was observed 13 (median; range 9–31) days after SCT . Increase in immature platelet fraction (IPF) before platelet recovery was seen in all autologous SCT patients. Optimal cutoff IPF was found to be 5.3% for platelet recovery within 2 d (specificity 0.98, sensitivity 0.47, positive predictive value 0.93). Conclusions We identified an optimal cutoff value for IPF 5.3% to predict platelet recovery after autologous SCT within 2 d. Implementing this cutoff value in transfusion strategy may reduce the number of prophylactic platelet transfusions." @default.
- W2002173692 created "2016-06-24" @default.
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- W2002173692 date "2014-04-25" @default.
- W2002173692 modified "2023-10-06" @default.
- W2002173692 title "Immature platelet fraction measured on the <scp>S</scp> ysmex <scp>XN</scp> hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation" @default.
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- W2002173692 doi "https://doi.org/10.1111/ejh.12319" @default.
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