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- W2002173977 abstract "Les mitochondries de foie de rat ne sont pas pleinement fonctionnelles à la naissance. Les relations entre cette déficience et l'affinité de ces mitochondries pour le phosphate, au cours de la synthèse d'ATP liée à l'oxydation du succinate ou au cours du transport du phosphate, ont été étudiées. La concentration en phosphate nécessaire pour obtenir une vitesse maximum d'oxydation du succinate en présence d'ADP est plus élevée chez les mitochondries de nouveau-né que chez celles de l'adulte. Après préincubation des mitochondries de nouveau-né avec de l'ATP, la vitesse d'oxydation du succinate en présence d'ADP augmente avec la concentration en phosphate de la même manière que chez l'adulte. La vitesse maximale d'échange phosphate-acétate, qui est une mesure indirecte de la vitesse du transport de phosphate à travers la membrane mitochondriale, n'est pas significativement différente pour les mitochondries de foie de rat adulte ou nouveau-né. Au contraire l'affinité apparente pour le phosphate est environ 10 fois plus faible chez le nouveau-né que chez l'adulte. Rat liver mitochondria are not fully functional at birth. The relationship between this deficiency and the affinity for phosphate, in oxidative phosphorylation or in phosphate transport, have been studied. The phosphate concentration necessary to observe maximal rate of succinate oxidation in the presence of ADP was higher for newborn than for adult rat liver mitochondria. After preincubation of newborn rat liver mitochondria with ATP, the rate of succinate oxidation in the presence of ADP increased with phosphate concentration similarly for newborn and adult rat liver mitochondria. The maximal rate of phosphate-acetate exchange, which is an indirect measure of the rate of phosphate transport across the mitochondrial membrane, was not significantly different for adult and newborn rat liver mitochondria. On the contrary the apparent affinity for phosphate was about ten-fold lower for newborn than for adult mitochondria." @default.
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- W2002173977 date "1984-02-01" @default.
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- W2002173977 title "High phosphate requirement for oxidative phosphorylation and low affinity for phosphate transport in newborn rat liver mitochondria" @default.
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- W2002173977 doi "https://doi.org/10.1016/s0300-9084(84)80033-4" @default.
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