FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002175080> ?p ?o ?g. }

• W2002175080 endingPage "292" @default.
• W2002175080 startingPage "286" @default.
• W2002175080 abstract "A group of potential differentiation-associated genes had been identified by microarray analysis as c-Jun/AP-1 target genes essential for epithelial differentiation program. Our previous study showed that c-Jun/AP-1 could bind and activate these gene promoters in vivo using chromatin immunoprecipitation. To further understand how the mitogen-activated protein kinase signaling pathways regulate AP-1 activity and expression of c-Jun target genes, our strategy was based on the use of 12-o-tetradecanoylophorbol-13-acetate (TPA) and pharmacological reagents to induce or block c-Jun expression. The mRNA and protein expression of these genes increased in response to TPA-induced c-Jun/AP-1 expression. Inhibitors of JNK (SP600125) and PKC (GF109203X) mainly blocked expression and phosphorylation of c-Jun, while inhibition of MEK-ERK activity with PD98059 (an inhibitor of MEK) had little effect. Expression of involucrin and keratin 4 in response to TPA was attenuated by pretreatments with GF109203X and SP600125, but not PD98059, suggesting involvement of PKC and JNK in this response. Taken together, these results suggested that differentiation-associated genes were regulated by TPA-induced c-Jun/AP-1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450." @default.
• W2002175080 created "2016-06-24" @default.
• W2002175080 creator A5002238001 @default.
• W2002175080 creator A5031817044 @default.
• W2002175080 creator A5036475409 @default.
• W2002175080 creator A5055765857 @default.
• W2002175080 creator A5065829118 @default.
• W2002175080 creator A5086317474 @default.
• W2002175080 creator A5091250034 @default.
• W2002175080 date "2006-03-01" @default.
• W2002175080 modified "2023-09-24" @default.
• W2002175080 title "Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells" @default.
• W2002175080 cites W1521237417 @default.
• W2002175080 cites W1527547321 @default.
• W2002175080 cites W1539871462 @default.
• W2002175080 cites W1555489233 @default.
• W2002175080 cites W1799809595 @default.
• W2002175080 cites W1911507086 @default.
• W2002175080 cites W1965186367 @default.
• W2002175080 cites W1967004332 @default.
• W2002175080 cites W1977302628 @default.
• W2002175080 cites W1982496758 @default.
• W2002175080 cites W1984665850 @default.
• W2002175080 cites W1984903682 @default.
• W2002175080 cites W1986157687 @default.
• W2002175080 cites W1987352835 @default.
• W2002175080 cites W1994908495 @default.
• W2002175080 cites W1996405087 @default.
• W2002175080 cites W2000482214 @default.
• W2002175080 cites W2003058837 @default.
• W2002175080 cites W2005900169 @default.
• W2002175080 cites W2007986629 @default.
• W2002175080 cites W2009781189 @default.
• W2002175080 cites W2010324176 @default.
• W2002175080 cites W2015471428 @default.
• W2002175080 cites W2028753942 @default.
• W2002175080 cites W2036224418 @default.
• W2002175080 cites W2055569826 @default.
• W2002175080 cites W2063469056 @default.
• W2002175080 cites W2073548049 @default.
• W2002175080 cites W2076485183 @default.
• W2002175080 cites W2081135713 @default.
• W2002175080 cites W2088013507 @default.
• W2002175080 cites W2138779676 @default.
• W2002175080 cites W2396979416 @default.
• W2002175080 doi "https://doi.org/10.1016/j.bbrc.2006.01.147" @default.
• W2002175080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16480952" @default.
• W2002175080 hasPublicationYear "2006" @default.
• W2002175080 type Work @default.
• W2002175080 sameAs 2002175080 @default.
• W2002175080 citedByCount "15" @default.
• W2002175080 countsByYear W20021750802012 @default.
• W2002175080 countsByYear W20021750802013 @default.
• W2002175080 countsByYear W20021750802014 @default.
• W2002175080 countsByYear W20021750802016 @default.
• W2002175080 countsByYear W20021750802022 @default.
• W2002175080 crossrefType "journal-article" @default.
• W2002175080 hasAuthorship W2002175080A5002238001 @default.
• W2002175080 hasAuthorship W2002175080A5031817044 @default.
• W2002175080 hasAuthorship W2002175080A5036475409 @default.
• W2002175080 hasAuthorship W2002175080A5055765857 @default.
• W2002175080 hasAuthorship W2002175080A5065829118 @default.
• W2002175080 hasAuthorship W2002175080A5086317474 @default.
• W2002175080 hasAuthorship W2002175080A5091250034 @default.
• W2002175080 hasConcept C101762097 @default.
• W2002175080 hasConcept C104317684 @default.
• W2002175080 hasConcept C1292079 @default.
• W2002175080 hasConcept C134320426 @default.
• W2002175080 hasConcept C150194340 @default.
• W2002175080 hasConcept C153911025 @default.
• W2002175080 hasConcept C184235292 @default.
• W2002175080 hasConcept C185592680 @default.
• W2002175080 hasConcept C195794163 @default.
• W2002175080 hasConcept C2779087070 @default.
• W2002175080 hasConcept C55493867 @default.
• W2002175080 hasConcept C57074206 @default.
• W2002175080 hasConcept C62478195 @default.
• W2002175080 hasConcept C86339819 @default.
• W2002175080 hasConcept C86803240 @default.
• W2002175080 hasConcept C95444343 @default.
• W2002175080 hasConceptScore W2002175080C101762097 @default.
• W2002175080 hasConceptScore W2002175080C104317684 @default.
• W2002175080 hasConceptScore W2002175080C1292079 @default.
• W2002175080 hasConceptScore W2002175080C134320426 @default.
• W2002175080 hasConceptScore W2002175080C150194340 @default.
• W2002175080 hasConceptScore W2002175080C153911025 @default.
• W2002175080 hasConceptScore W2002175080C184235292 @default.
• W2002175080 hasConceptScore W2002175080C185592680 @default.
• W2002175080 hasConceptScore W2002175080C195794163 @default.
• W2002175080 hasConceptScore W2002175080C2779087070 @default.
• W2002175080 hasConceptScore W2002175080C55493867 @default.
• W2002175080 hasConceptScore W2002175080C57074206 @default.
• W2002175080 hasConceptScore W2002175080C62478195 @default.
• W2002175080 hasConceptScore W2002175080C86339819 @default.
• W2002175080 hasConceptScore W2002175080C86803240 @default.
• W2002175080 hasConceptScore W2002175080C95444343 @default.
• W2002175080 hasIssue "1" @default.
• W2002175080 hasLocation W20021750801 @default.

• next