Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002175799> ?p ?o ?g. }
- W2002175799 endingPage "1146" @default.
- W2002175799 startingPage "1146" @default.
- W2002175799 abstract "Purpose: To evaluate the involvement of apoptosis in N-methyl-D-aspartate (NMDA)-induced excitotoxicity in the rabbit retina. Methods: After intravitreal injection of 680 and 2,000 nmoles of NMDA in rabbit eyes, the eyes were enucleated at 2, 16, and 60 hours and 1 and 2 weeks. The apoptotic cell death was determined with TdT-mediated biotin-dUTP nick end labeling (TUNEL) stain, and immunohistochemical stains of Bcl-2, Bax, and caspase-3 were performed. Results: TUNEL showed increased labeling scattered in the ganglion cell layer and inner nuclear layer from 16 to 60 hours. The number of TUNEL-positive nuclei decreased at 60 hours, and none was observed at 2 hours, 1 week, and 2 weeks. More TUNEL-positive nuclei were seen with injection of 2,000 nmoles compared to 680 nmoles. Bcl-2, Bax, and caspase-3 were seen histologically as early as 2 hours in the ganglion cell layer and inner nuclear layer; there was no stained nuclei with the TUNEL stain. At 2 hours after intravitreal NMDA injection, Bcl-2, Bax, and caspase-3 were also stained in Muller cells. Conclusions: This study showed that apoptosis is involved in NMDA-induced excitotoxicity in the rabbit retina. Bcl-2, Bax, and caspase-3 may play important roles in modulating the apoptosis in NMDA-induced excitotoxicity, and Muller cells are involved in the apoptotic pathway." @default.
- W2002175799 created "2016-06-24" @default.
- W2002175799 creator A5020191539 @default.
- W2002175799 creator A5033544661 @default.
- W2002175799 creator A5045449915 @default.
- W2002175799 creator A5053406416 @default.
- W2002175799 creator A5053757405 @default.
- W2002175799 creator A5054980047 @default.
- W2002175799 creator A5069489177 @default.
- W2002175799 date "2008-01-01" @default.
- W2002175799 modified "2023-10-18" @default.
- W2002175799 title "N-Methyl-D-Aspartate (NMDA)-induced Apoptosis in Rabbit Retina" @default.
- W2002175799 cites W1551549641 @default.
- W2002175799 cites W1585639756 @default.
- W2002175799 cites W1601632182 @default.
- W2002175799 cites W1971548413 @default.
- W2002175799 cites W1973111465 @default.
- W2002175799 cites W1975951192 @default.
- W2002175799 cites W1980442975 @default.
- W2002175799 cites W1984977607 @default.
- W2002175799 cites W1997208169 @default.
- W2002175799 cites W2016575029 @default.
- W2002175799 cites W2025008185 @default.
- W2002175799 cites W2031539368 @default.
- W2002175799 cites W2034454128 @default.
- W2002175799 cites W2037473273 @default.
- W2002175799 cites W2041644100 @default.
- W2002175799 cites W2050477129 @default.
- W2002175799 cites W2051916700 @default.
- W2002175799 cites W2053577892 @default.
- W2002175799 cites W2056429791 @default.
- W2002175799 cites W2057713336 @default.
- W2002175799 cites W2062051253 @default.
- W2002175799 cites W2062807784 @default.
- W2002175799 cites W2063176993 @default.
- W2002175799 cites W2063804633 @default.
- W2002175799 cites W2071452513 @default.
- W2002175799 cites W2074792377 @default.
- W2002175799 cites W2084096897 @default.
- W2002175799 cites W2084352924 @default.
- W2002175799 cites W2086305194 @default.
- W2002175799 cites W2088465844 @default.
- W2002175799 cites W2092709998 @default.
- W2002175799 cites W2093684206 @default.
- W2002175799 cites W2124312551 @default.
- W2002175799 cites W2134979684 @default.
- W2002175799 cites W2138302361 @default.
- W2002175799 cites W2146983373 @default.
- W2002175799 cites W2155747798 @default.
- W2002175799 cites W2161023348 @default.
- W2002175799 cites W2162522735 @default.
- W2002175799 cites W2320101893 @default.
- W2002175799 cites W2407640022 @default.
- W2002175799 cites W4298841157 @default.
- W2002175799 doi "https://doi.org/10.3341/jkos.2008.49.7.1146" @default.
- W2002175799 hasPublicationYear "2008" @default.
- W2002175799 type Work @default.
- W2002175799 sameAs 2002175799 @default.
- W2002175799 citedByCount "2" @default.
- W2002175799 countsByYear W20021757992014 @default.
- W2002175799 crossrefType "journal-article" @default.
- W2002175799 hasAuthorship W2002175799A5020191539 @default.
- W2002175799 hasAuthorship W2002175799A5033544661 @default.
- W2002175799 hasAuthorship W2002175799A5045449915 @default.
- W2002175799 hasAuthorship W2002175799A5053406416 @default.
- W2002175799 hasAuthorship W2002175799A5053757405 @default.
- W2002175799 hasAuthorship W2002175799A5054980047 @default.
- W2002175799 hasAuthorship W2002175799A5069489177 @default.
- W2002175799 hasBestOaLocation W20021757991 @default.
- W2002175799 hasConcept C105795698 @default.
- W2002175799 hasConcept C118487528 @default.
- W2002175799 hasConcept C126322002 @default.
- W2002175799 hasConcept C169760540 @default.
- W2002175799 hasConcept C170493617 @default.
- W2002175799 hasConcept C185592680 @default.
- W2002175799 hasConcept C190283241 @default.
- W2002175799 hasConcept C2777093970 @default.
- W2002175799 hasConcept C2779884254 @default.
- W2002175799 hasConcept C33923547 @default.
- W2002175799 hasConcept C55493867 @default.
- W2002175799 hasConcept C67018056 @default.
- W2002175799 hasConcept C71924100 @default.
- W2002175799 hasConcept C86803240 @default.
- W2002175799 hasConcept C98274493 @default.
- W2002175799 hasConceptScore W2002175799C105795698 @default.
- W2002175799 hasConceptScore W2002175799C118487528 @default.
- W2002175799 hasConceptScore W2002175799C126322002 @default.
- W2002175799 hasConceptScore W2002175799C169760540 @default.
- W2002175799 hasConceptScore W2002175799C170493617 @default.
- W2002175799 hasConceptScore W2002175799C185592680 @default.
- W2002175799 hasConceptScore W2002175799C190283241 @default.
- W2002175799 hasConceptScore W2002175799C2777093970 @default.
- W2002175799 hasConceptScore W2002175799C2779884254 @default.
- W2002175799 hasConceptScore W2002175799C33923547 @default.
- W2002175799 hasConceptScore W2002175799C55493867 @default.
- W2002175799 hasConceptScore W2002175799C67018056 @default.
- W2002175799 hasConceptScore W2002175799C71924100 @default.
- W2002175799 hasConceptScore W2002175799C86803240 @default.