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- W2002176383 abstract "A novel test was developed to measure the tracheobronchial irritant activity of inhaled prostaglandins. Conscious restrained cats were challenged with seperate aerosols of PGE1, PGF2α, acetylcholine or isoprenaline. All of the aerosols except isoprenaline caused coughing in a concentration related manner. Tolerance developed very quickly to the tracheobronchial irritation and lasted 1–2 days for PGE1 and less than 1 day for PGF2α and acetylcholine. When a 3 day interval between each aerosol challenge was used, PGF2α was approximately 700 times more potent than acetylcholine as a tracheobronchial irritant. The highest PGE1 aerosol concentration (500 μg/ml) also caused sedation, diarrhoea and salivation. This test probably provides a useful method for evaluating the tracheobronchial irritant activity of potential prostaglandin bronchodilator analogues and for investigating the mechanism of action of prostaglandin induced tracheobronchial irritancy." @default.
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- W2002176383 date "1978-02-01" @default.
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- W2002176383 title "Tracheobronchial irritancy of inhaled prostaglandins in the conscious cat" @default.
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- W2002176383 doi "https://doi.org/10.1016/0090-6980(78)90170-3" @default.
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