FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002177738> ?p ?o ?g. }

• W2002177738 abstract "Abstract Background Entamoeba histolytica and Entamoeba dispar are closely related protistan parasites but while E. histolytica can be invasive, E. dispar is completely non pathogenic. Transposable elements constitute a significant portion of the genome in these species; there being three families of LINEs and SINEs. These elements can profoundly influence the expression of neighboring genes. Thus their genomic location can have important phenotypic consequences. A genome-wide comparison of the location of these elements in the E. histolytica and E. dispar genomes has not been carried out. It is also not known whether the retrotransposition machinery works similarly in both species. The present study was undertaken to address these issues. Results Here we extracted all genomic occurrences of full-length copies of EhSINE1 in the E. histolytica genome and matched them with the homologous regions in E. dispar , and vice versa, wherever it was possible to establish synteny. We found that only about 20% of syntenic sites were occupied by SINE1 in both species. We checked whether the different genomic location in the two species was due to differences in the activity of the LINE-encoded endonuclease which is required for nicking the target site. We found that the endonucleases of both species were essentially very similar, both in their kinetic properties and in their substrate sequence specificity. Hence the differential distribution of SINEs in these species is not likely to be influenced by the endonuclease. Further we found that the physical properties of the DNA sequences adjoining the insertion sites were similar in both species. Conclusions Our data shows that the basic retrotransposition machinery is conserved in these sibling species. SINEs may indeed have occupied all of the insertion sites in the genome of the common ancestor of E. histolytica and E. dispar but these may have been subsequently lost from some locations. Alternatively, SINE expansion took place after the divergence of the two species. The absence of SINE1 in 80% of syntenic loci could affect the phenotype of the two species, including their pathogenic properties, which needs to be explored." @default.
• W2002177738 created "2016-06-24" @default.
• W2002177738 creator A5026725255 @default.
• W2002177738 creator A5027227742 @default.
• W2002177738 creator A5031877851 @default.
• W2002177738 creator A5037710598 @default.
• W2002177738 creator A5056524863 @default.
• W2002177738 creator A5072103359 @default.
• W2002177738 date "2011-05-25" @default.
• W2002177738 modified "2023-10-08" @default.
• W2002177738 title "Differential distribution of a SINE element in the Entamoeba histolytica and Entamoeba dispar genomes: Role of the LINE-encoded endonuclease" @default.
• W2002177738 cites W1965074434 @default.
• W2002177738 cites W1987022258 @default.
• W2002177738 cites W1991333931 @default.
• W2002177738 cites W1993988294 @default.
• W2002177738 cites W2011424650 @default.
• W2002177738 cites W2039944105 @default.
• W2002177738 cites W2041907973 @default.
• W2002177738 cites W2073322753 @default.
• W2002177738 cites W2080512035 @default.
• W2002177738 cites W2085026014 @default.
• W2002177738 cites W2089776466 @default.
• W2002177738 cites W2090978648 @default.
• W2002177738 cites W2094844116 @default.
• W2002177738 cites W2103148772 @default.
• W2002177738 cites W2108312185 @default.
• W2002177738 cites W2108717023 @default.
• W2002177738 cites W2130063668 @default.
• W2002177738 cites W2143755038 @default.
• W2002177738 cites W2145598239 @default.
• W2002177738 cites W2146117737 @default.
• W2002177738 cites W2151466932 @default.
• W2002177738 cites W2153586836 @default.
• W2002177738 cites W2156452836 @default.
• W2002177738 cites W2157890550 @default.
• W2002177738 doi "https://doi.org/10.1186/1471-2164-12-267" @default.
• W2002177738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118788" @default.
• W2002177738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21612594" @default.
• W2002177738 hasPublicationYear "2011" @default.
• W2002177738 type Work @default.
• W2002177738 sameAs 2002177738 @default.
• W2002177738 citedByCount "13" @default.
• W2002177738 countsByYear W20021777382012 @default.
• W2002177738 countsByYear W20021777382013 @default.
• W2002177738 countsByYear W20021777382014 @default.
• W2002177738 countsByYear W20021777382015 @default.
• W2002177738 countsByYear W20021777382019 @default.
• W2002177738 countsByYear W20021777382021 @default.
• W2002177738 countsByYear W20021777382022 @default.
• W2002177738 crossrefType "journal-article" @default.
• W2002177738 hasAuthorship W2002177738A5026725255 @default.
• W2002177738 hasAuthorship W2002177738A5027227742 @default.
• W2002177738 hasAuthorship W2002177738A5031877851 @default.
• W2002177738 hasAuthorship W2002177738A5037710598 @default.
• W2002177738 hasAuthorship W2002177738A5056524863 @default.
• W2002177738 hasAuthorship W2002177738A5072103359 @default.
• W2002177738 hasBestOaLocation W20021777381 @default.
• W2002177738 hasConcept C104317684 @default.
• W2002177738 hasConcept C128319531 @default.
• W2002177738 hasConcept C141231307 @default.
• W2002177738 hasConcept C2776867272 @default.
• W2002177738 hasConcept C2777028655 @default.
• W2002177738 hasConcept C2779052163 @default.
• W2002177738 hasConcept C4918238 @default.
• W2002177738 hasConcept C53702515 @default.
• W2002177738 hasConcept C54355233 @default.
• W2002177738 hasConcept C552990157 @default.
• W2002177738 hasConcept C86803240 @default.
• W2002177738 hasConceptScore W2002177738C104317684 @default.
• W2002177738 hasConceptScore W2002177738C128319531 @default.
• W2002177738 hasConceptScore W2002177738C141231307 @default.
• W2002177738 hasConceptScore W2002177738C2776867272 @default.
• W2002177738 hasConceptScore W2002177738C2777028655 @default.
• W2002177738 hasConceptScore W2002177738C2779052163 @default.
• W2002177738 hasConceptScore W2002177738C4918238 @default.
• W2002177738 hasConceptScore W2002177738C53702515 @default.
• W2002177738 hasConceptScore W2002177738C54355233 @default.
• W2002177738 hasConceptScore W2002177738C552990157 @default.
• W2002177738 hasConceptScore W2002177738C86803240 @default.
• W2002177738 hasIssue "1" @default.
• W2002177738 hasLocation W20021777381 @default.
• W2002177738 hasLocation W20021777382 @default.
• W2002177738 hasLocation W20021777383 @default.
• W2002177738 hasLocation W20021777384 @default.
• W2002177738 hasLocation W20021777385 @default.
• W2002177738 hasOpenAccess W2002177738 @default.
• W2002177738 hasPrimaryLocation W20021777381 @default.
• W2002177738 hasRelatedWork W1981374009 @default.
• W2002177738 hasRelatedWork W2002177738 @default.
• W2002177738 hasRelatedWork W2017354604 @default.
• W2002177738 hasRelatedWork W2039944105 @default.
• W2002177738 hasRelatedWork W2119233950 @default.
• W2002177738 hasRelatedWork W2160303520 @default.
• W2002177738 hasRelatedWork W2783893042 @default.
• W2002177738 hasRelatedWork W3160067893 @default.
• W2002177738 hasRelatedWork W4205666787 @default.
• W2002177738 hasRelatedWork W2551607548 @default.
• W2002177738 hasVolume "12" @default.
• W2002177738 isParatext "false" @default.
• W2002177738 isRetracted "false" @default.

• next