FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002179621> ?p ?o ?g. }

• W2002179621 endingPage "670" @default.
• W2002179621 startingPage "656" @default.
• W2002179621 abstract "Preconditioning may find ready applicability in humans facing scheduled global cardiac ischemia-reperfusion (IR) during bypass or transplantation, where such a maneuver is feasible before arrest. Our objective was to delineate and exploit the endogenous preconditioning mechanism triggered by transient ischemia (TI) and thereby attenuate myocardial postischemic mechanical dysfunction by clinically acceptable means. Preconditioning by 2 minutes of TI followed by 10 minutes of normal perfusion protected isolated rat left ventricle function assessed after 20 minutes of global, 37 degrees C ischemia and 40 minutes of reperfusion. Final recovery of developed pressure (DP) was improved (91.5 +/- 1.9% of equilibration DP versus unconditioned IR control, 57.4 +/- 2.4%, P < .01) and was accompanied by increased contractility (+/- dP/dt). Norepinephrine release increased after TI, and reserpine pretreatment abolished TI preconditioning. This suggests that endogenous norepinephrine mediates functional preconditioning in rat. Brief pretreatment (2 minutes) with exogenous norepinephrine reproduced the protection (89.1 +/- 1.4%) of postischemic function. Functional protection persisted after the hemodynamic effects had resolved. Norepinephrine-induced preconditioning was simulated by phenylephrine and blocked by alpha 1-adrenergic receptor antagonist. TI preconditioning was similarly lost after selective alpha 1-adrenergic receptor blockade. We conclude that transient ischemic preconditioning is mediated by the sympathetic neurotransmitter release and alpha 1-adrenergic receptor stimulation. Although the postreceptor mechanism remains unclear, functional protection after IR does not seem related to the magnitude of ATP depletion and elevation of resting pressure during ischemia. Rather, the endogenous mechanisms facilitate both recovery of mechanical function and ATP repletion during reperfusion." @default.
• W2002179621 created "2016-06-24" @default.
• W2002179621 creator A5004545352 @default.
• W2002179621 creator A5010301513 @default.
• W2002179621 creator A5040255031 @default.
• W2002179621 creator A5045184087 @default.
• W2002179621 creator A5058164284 @default.
• W2002179621 creator A5064465348 @default.
• W2002179621 creator A5085039775 @default.
• W2002179621 creator A5087253902 @default.
• W2002179621 date "1993-10-01" @default.
• W2002179621 modified "2023-10-15" @default.
• W2002179621 title "Preconditioning against myocardial dysfunction after ischemia and reperfusion by an alpha 1-adrenergic mechanism." @default.
• W2002179621 cites W1512854463 @default.
• W2002179621 cites W163159731 @default.
• W2002179621 cites W1841809633 @default.
• W2002179621 cites W1959138509 @default.
• W2002179621 cites W1980166477 @default.
• W2002179621 cites W2004145281 @default.
• W2002179621 cites W2008972347 @default.
• W2002179621 cites W2017567063 @default.
• W2002179621 cites W2018032623 @default.
• W2002179621 cites W2024316762 @default.
• W2002179621 cites W2036227941 @default.
• W2002179621 cites W2046996305 @default.
• W2002179621 cites W2048652590 @default.
• W2002179621 cites W2057596639 @default.
• W2002179621 cites W2075684844 @default.
• W2002179621 cites W2078416377 @default.
• W2002179621 cites W2082186975 @default.
• W2002179621 cites W2084926943 @default.
• W2002179621 cites W2086524338 @default.
• W2002179621 cites W2104480181 @default.
• W2002179621 cites W2122297682 @default.
• W2002179621 cites W2133488495 @default.
• W2002179621 cites W2165523226 @default.
• W2002179621 cites W2294696122 @default.
• W2002179621 cites W2400926869 @default.
• W2002179621 cites W2412856908 @default.
• W2002179621 cites W607092207 @default.
• W2002179621 cites W962318799 @default.
• W2002179621 doi "https://doi.org/10.1161/01.res.73.4.656" @default.
• W2002179621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8396503" @default.
• W2002179621 hasPublicationYear "1993" @default.
• W2002179621 type Work @default.
• W2002179621 sameAs 2002179621 @default.
• W2002179621 citedByCount "377" @default.
• W2002179621 countsByYear W20021796212012 @default.
• W2002179621 countsByYear W20021796212013 @default.
• W2002179621 countsByYear W20021796212014 @default.
• W2002179621 countsByYear W20021796212015 @default.
• W2002179621 countsByYear W20021796212016 @default.
• W2002179621 countsByYear W20021796212017 @default.
• W2002179621 countsByYear W20021796212018 @default.
• W2002179621 countsByYear W20021796212019 @default.
• W2002179621 countsByYear W20021796212021 @default.
• W2002179621 countsByYear W20021796212022 @default.
• W2002179621 countsByYear W20021796212023 @default.
• W2002179621 crossrefType "journal-article" @default.
• W2002179621 hasAuthorship W2002179621A5004545352 @default.
• W2002179621 hasAuthorship W2002179621A5010301513 @default.
• W2002179621 hasAuthorship W2002179621A5040255031 @default.
• W2002179621 hasAuthorship W2002179621A5045184087 @default.
• W2002179621 hasAuthorship W2002179621A5058164284 @default.
• W2002179621 hasAuthorship W2002179621A5064465348 @default.
• W2002179621 hasAuthorship W2002179621A5085039775 @default.
• W2002179621 hasAuthorship W2002179621A5087253902 @default.
• W2002179621 hasBestOaLocation W20021796211 @default.
• W2002179621 hasConcept C126322002 @default.
• W2002179621 hasConcept C146957229 @default.
• W2002179621 hasConcept C158453852 @default.
• W2002179621 hasConcept C16613235 @default.
• W2002179621 hasConcept C170493617 @default.
• W2002179621 hasConcept C2777842393 @default.
• W2002179621 hasConcept C2778514916 @default.
• W2002179621 hasConcept C2779311647 @default.
• W2002179621 hasConcept C2779676291 @default.
• W2002179621 hasConcept C2780114680 @default.
• W2002179621 hasConcept C39133596 @default.
• W2002179621 hasConcept C40465926 @default.
• W2002179621 hasConcept C42219234 @default.
• W2002179621 hasConcept C513476851 @default.
• W2002179621 hasConcept C541997718 @default.
• W2002179621 hasConcept C71924100 @default.
• W2002179621 hasConceptScore W2002179621C126322002 @default.
• W2002179621 hasConceptScore W2002179621C146957229 @default.
• W2002179621 hasConceptScore W2002179621C158453852 @default.
• W2002179621 hasConceptScore W2002179621C16613235 @default.
• W2002179621 hasConceptScore W2002179621C170493617 @default.
• W2002179621 hasConceptScore W2002179621C2777842393 @default.
• W2002179621 hasConceptScore W2002179621C2778514916 @default.
• W2002179621 hasConceptScore W2002179621C2779311647 @default.
• W2002179621 hasConceptScore W2002179621C2779676291 @default.
• W2002179621 hasConceptScore W2002179621C2780114680 @default.
• W2002179621 hasConceptScore W2002179621C39133596 @default.
• W2002179621 hasConceptScore W2002179621C40465926 @default.
• W2002179621 hasConceptScore W2002179621C42219234 @default.
• W2002179621 hasConceptScore W2002179621C513476851 @default.

• next