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• W2002182550 abstract "Abstract: [3H]Hemicholinium-3 (HC-3) was used to label sodium-dependent, high-affinity choline uptake sites in regions of rat brain. Autoradiography revealed a high density of [3H]HC-3 binding sites in brain regions with a high density of cholinergic terminals, such as the interpeduncular nucleus, caudate-putamen, and olfactory tubercle. This distribution of [3H]HC-3 binding sites was in close agreement with the amounts of choline acetyltrans-ferase in specific nuclei and subregions of rat brain. Destruction of presynaptic cholinergic projections in the cerebral cortex and the basal ganglia by injection of excitotoxins reduced [3H]HC-3 binding by 40–50%. These data indicate that sodium-dependent [3H]HC-3 binding sites are related to the choline transport system present in cholinergic neurons." @default.
• W2002182550 created "2016-06-24" @default.
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• W2002182550 date "1986-02-01" @default.
• W2002182550 modified "2023-10-17" @default.
• W2002182550 title "Identification of Sodium-Dependent, High-Affinity Choline Uptake Sites in Rat Brain with [³H]Hemicholinium-3" @default.
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• W2002182550 doi "https://doi.org/10.1111/j.1471-4159.1986.tb12993.x" @default.
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