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- W2002183852 abstract "Objective: Given the association between salt-sensitivity of blood pressure (BP) and risk of future hypertension (HPT), we investigated the predictive role of alterations in segmental renal tubular sodium handling in the development of HPT during the 8 year follow-up of the Olivetti Heart Study participants. Methods: A selected sample (n = 314) of OHS population was examined at baseline and after 8 years. The participants were included if they were normotensive (SBP/DBP <140/90 mm Hg without anti-hypertensive treatment) and had normal renal function (creatinine clearance - CrCl> 60 ml/min) at baseline. Proximal and distal fractional tubular sodium reabsorption were calculated using the clearance of exogenous lithium. Results: The baseline sample characteristics were: age 49.3 ± 6.8 yrs, BMI 26.4 ± 2.8 kg/m2, SBP/DBP 119.8 ± 9.6/78.9 ± 6.4 mm Hg, CrCl 90.9 ± 18.2 mL/min (M ± SD). The HPT incidence in 8 years was 52%. The participants who developed HPT (group A) compared with those who did not (group B) had higher baseline SBP (122.4 ± 8.4 mm Hg vs 117.0 ± 10.0, p < 0.0001), DBP (80.6 ± 5.6 VS 77.1 ± 6.7 mm Hg, p < 0.0001), BMI (27.0 ± 2.9 vs 25.9 ± 2.6 kg/m2, p < 0.0001) and fractional proximal reabsorption of sodium (75.8 ± 6.3 vs 73.8 ± 7.3 %, p = 0.01). At logistic regression analysis using standardised variables, a 1SD-higher proximal sodium reabsorption at baseline predicted a 44% greater risk of HPT in 8 years (95% C.I. 13–84, p = 0.003), independently of baseline SBP (OR: 1.88, 95% C.I. 1.43–2.47, p < 0.001), BMI (OR: 1.51, 95% C.I. 1.16–1.95, p = 0.002), age and creatinine clearance used as an index of glomerular filtration rate. Conclusions: In this sample of healthy adult male population, proximal sodium reabsorption indexed to glomerular filtration rate was an independent predictor of future HPT." @default.
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- W2002183852 date "2010-06-01" @default.
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- W2002183852 title "PROXIMAL SODIUM REABSORPTION IS AN INDEPENDENT PREDICTOR OF HYPERTENSION: 2D.05" @default.
- W2002183852 doi "https://doi.org/10.1097/01.hjh.0000378289.20426.60" @default.
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