Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002186145> ?p ?o ?g. }
- W2002186145 endingPage "98" @default.
- W2002186145 startingPage "91" @default.
- W2002186145 abstract "Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), has been extensively used in traditional oriental medicine for the prevention and treatment of aging-related disorders for over 2000 years. Accumulating evidence suggests that ginsenosides such as Rg1 and Rb1, which are the pharmacologically active ingredients of ginseng, modulate neurotransmission. Synapsins are abundant phosphoproteins essential for regulating neurotransmitter release. All synapsins contain a short amino-terminal domain A that is highly conserved and phosphorylated by cAMP-dependent protein kinase (PKA), which plays a key role in regulating neurotransmitter release. In the present study, we demonstrated that both Rg1 and Rb1 increased neurotransmitter release in undifferentiated and differentiated PC12 cells. However, in the presence of the PKA inhibitor H89, Rg1, but not Rb1, still induced neurotransmitter release. Moreover, Rb1, but not Rg1, enhanced the phosphorylation of synapsins via PKA pathway. In summary, Rb1 promotes neurotransmitter release by increasing the phosphorylation of synapsins through the PKA pathway, whereas the similar effects observed with Rg1 are independent of the phosphorylation of synapsins." @default.
- W2002186145 created "2016-06-24" @default.
- W2002186145 creator A5006614163 @default.
- W2002186145 creator A5023589940 @default.
- W2002186145 creator A5064530138 @default.
- W2002186145 creator A5066762784 @default.
- W2002186145 creator A5087364900 @default.
- W2002186145 creator A5088517105 @default.
- W2002186145 date "2006-08-01" @default.
- W2002186145 modified "2023-10-17" @default.
- W2002186145 title "Ginsenoside Rb1 promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway" @default.
- W2002186145 cites W1564969903 @default.
- W2002186145 cites W1964961008 @default.
- W2002186145 cites W1965244669 @default.
- W2002186145 cites W1965716459 @default.
- W2002186145 cites W1974107274 @default.
- W2002186145 cites W1978747281 @default.
- W2002186145 cites W1985722583 @default.
- W2002186145 cites W1986553796 @default.
- W2002186145 cites W1993099285 @default.
- W2002186145 cites W1997058330 @default.
- W2002186145 cites W2002944269 @default.
- W2002186145 cites W2010313687 @default.
- W2002186145 cites W2011946830 @default.
- W2002186145 cites W2022046189 @default.
- W2002186145 cites W2022740810 @default.
- W2002186145 cites W2036207338 @default.
- W2002186145 cites W2037210922 @default.
- W2002186145 cites W2039202482 @default.
- W2002186145 cites W2041199542 @default.
- W2002186145 cites W2044468559 @default.
- W2002186145 cites W2045122061 @default.
- W2002186145 cites W2049511526 @default.
- W2002186145 cites W2054683291 @default.
- W2002186145 cites W2061260576 @default.
- W2002186145 cites W2064862494 @default.
- W2002186145 cites W2065814598 @default.
- W2002186145 cites W2067481095 @default.
- W2002186145 cites W2072803007 @default.
- W2002186145 cites W2075663222 @default.
- W2002186145 cites W2081174120 @default.
- W2002186145 cites W2082270617 @default.
- W2002186145 cites W2085825273 @default.
- W2002186145 cites W2087036140 @default.
- W2002186145 cites W2088309103 @default.
- W2002186145 cites W2094565395 @default.
- W2002186145 cites W2096224929 @default.
- W2002186145 cites W2147051256 @default.
- W2002186145 cites W2148281839 @default.
- W2002186145 cites W2154100802 @default.
- W2002186145 cites W4239586912 @default.
- W2002186145 doi "https://doi.org/10.1016/j.brainres.2006.05.106" @default.
- W2002186145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16836988" @default.
- W2002186145 hasPublicationYear "2006" @default.
- W2002186145 type Work @default.
- W2002186145 sameAs 2002186145 @default.
- W2002186145 citedByCount "70" @default.
- W2002186145 countsByYear W20021861452012 @default.
- W2002186145 countsByYear W20021861452013 @default.
- W2002186145 countsByYear W20021861452014 @default.
- W2002186145 countsByYear W20021861452015 @default.
- W2002186145 countsByYear W20021861452016 @default.
- W2002186145 countsByYear W20021861452017 @default.
- W2002186145 countsByYear W20021861452018 @default.
- W2002186145 countsByYear W20021861452019 @default.
- W2002186145 countsByYear W20021861452020 @default.
- W2002186145 countsByYear W20021861452021 @default.
- W2002186145 countsByYear W20021861452022 @default.
- W2002186145 countsByYear W20021861452023 @default.
- W2002186145 crossrefType "journal-article" @default.
- W2002186145 hasAuthorship W2002186145A5006614163 @default.
- W2002186145 hasAuthorship W2002186145A5023589940 @default.
- W2002186145 hasAuthorship W2002186145A5064530138 @default.
- W2002186145 hasAuthorship W2002186145A5066762784 @default.
- W2002186145 hasAuthorship W2002186145A5087364900 @default.
- W2002186145 hasAuthorship W2002186145A5088517105 @default.
- W2002186145 hasConcept C11960822 @default.
- W2002186145 hasConcept C130316041 @default.
- W2002186145 hasConcept C142724271 @default.
- W2002186145 hasConcept C148785051 @default.
- W2002186145 hasConcept C170493617 @default.
- W2002186145 hasConcept C184235292 @default.
- W2002186145 hasConcept C185592680 @default.
- W2002186145 hasConcept C200170125 @default.
- W2002186145 hasConcept C204787440 @default.
- W2002186145 hasConcept C26987225 @default.
- W2002186145 hasConcept C2776219046 @default.
- W2002186145 hasConcept C2776539398 @default.
- W2002186145 hasConcept C2779232237 @default.
- W2002186145 hasConcept C2910715078 @default.
- W2002186145 hasConcept C41625074 @default.
- W2002186145 hasConcept C55493867 @default.
- W2002186145 hasConcept C71924100 @default.
- W2002186145 hasConcept C86803240 @default.
- W2002186145 hasConcept C87325107 @default.
- W2002186145 hasConcept C95444343 @default.
- W2002186145 hasConcept C97029542 @default.
- W2002186145 hasConcept C98274493 @default.