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- W2002187515 abstract "Leukemia L1210 cells were incubated in vitro with the tumor-localizing product HPD (hem-atoporphyrin derivative) for 0.5. 4 and 18 h. Effects of subsequent irradiation on viability, membrane transport and integrity, DNA synthesis and intracellular ATP concentration were assessed. Intracellular porphyrin pools were analyzed by HPLC. A 30 min incubation led to concentration of a readily-exchangeable pool of monomeric HPD components at plasma membrane loci; irradiation resulted in photodamage to membrane transport and a loss in capacity for dye exclusion. In contrast, increasing the incubation time led to a corresponding increase in the size of a non-exchangeable intracellular pool of other HPD components. Subsequent irradiation led to depletion of intracellular ATP and loss of capacity for biosynthesis of DNA, but little plasma membrane damage." @default.
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- W2002187515 date "1986-10-01" @default.
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- W2002187515 title "SITES OF PHOTOSENSITIZATION BY DERIVATIVES OF HEMATOPORPHYRIN" @default.
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- W2002187515 doi "https://doi.org/10.1111/j.1751-1097.1986.tb04697.x" @default.
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