FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002187542> ?p ?o ?g. }

• W2002187542 endingPage "40437" @default.
• W2002187542 startingPage "40427" @default.
• W2002187542 abstract "Activation of muscarinic acetylcholine receptors (mAChRs) in the spinal cord inhibits pain transmission. At least three mAChR subtypes (M(2), M(3), and M(4)) are present in the spinal dorsal horn. However, it is not clear how each mAChR subtype contributes to the regulation of glutamatergic input to dorsal horn neurons. We recorded spontaneous excitatory postsynaptic currents (sEPSCs) from lamina II neurons in spinal cord slices from wild-type (WT) and mAChR subtype knock-out (KO) mice. The mAChR agonist oxotremorine-M increased the frequency of glutamatergic sEPSCs in 68.2% neurons from WT mice and decreased the sEPSC frequency in 21.2% neurons. Oxotremorine-M also increased the sEPSC frequency in ∼50% neurons from M(3)-single KO and M(1)/M(3) double-KO mice. In addition, the M(3) antagonist J104129 did not block the stimulatory effect of oxotremorine-M in the majority of neurons from WT mice. Strikingly, in M(5)-single KO mice, oxotremorine-M increased sEPSCs in only 26.3% neurons, and J104129 abolished this effect. In M(2)/M(4) double-KO mice, but not M(2)- or M(4)-single KO mice, oxotremorine-M inhibited sEPSCs in significantly fewer neurons compared with WT mice, and blocking group II/III metabotropic glutamate receptors abolished this effect. The M(2)/M(4) antagonist himbacine either attenuated the inhibitory effect of oxotremorine-M or potentiated the stimulatory effect of oxotremorine-M in WT mice. Our study demonstrates that activation of the M(2) and M(4) receptor subtypes inhibits synaptic glutamate release to dorsal horn neurons. M(5) is the predominant receptor subtype that potentiates glutamatergic synaptic transmission in the spinal cord." @default.
• W2002187542 created "2016-06-24" @default.
• W2002187542 creator A5002812144 @default.
• W2002187542 creator A5015095365 @default.
• W2002187542 creator A5028551018 @default.
• W2002187542 creator A5038383431 @default.
• W2002187542 creator A5085520556 @default.
• W2002187542 date "2010-12-01" @default.
• W2002187542 modified "2023-10-14" @default.
• W2002187542 title "Dynamic Control of Glutamatergic Synaptic Input in the Spinal Cord by Muscarinic Receptor Subtypes Defined Using Knockout Mice" @default.
• W2002187542 cites W193068123 @default.
• W2002187542 cites W1964229131 @default.
• W2002187542 cites W1967340813 @default.
• W2002187542 cites W1967716998 @default.
• W2002187542 cites W1975724241 @default.
• W2002187542 cites W1980856647 @default.
• W2002187542 cites W1992063418 @default.
• W2002187542 cites W1994366671 @default.
• W2002187542 cites W2000902055 @default.
• W2002187542 cites W2002634671 @default.
• W2002187542 cites W2008913816 @default.
• W2002187542 cites W2012678551 @default.
• W2002187542 cites W2013068727 @default.
• W2002187542 cites W2015011246 @default.
• W2002187542 cites W2023180304 @default.
• W2002187542 cites W2023374499 @default.
• W2002187542 cites W2027693921 @default.
• W2002187542 cites W2041244640 @default.
• W2002187542 cites W2049344791 @default.
• W2002187542 cites W2050879963 @default.
• W2002187542 cites W2062156462 @default.
• W2002187542 cites W2064688182 @default.
• W2002187542 cites W2066129669 @default.
• W2002187542 cites W2068538092 @default.
• W2002187542 cites W2079397447 @default.
• W2002187542 cites W2081895446 @default.
• W2002187542 cites W2083867141 @default.
• W2002187542 cites W2090108559 @default.
• W2002187542 cites W2094347631 @default.
• W2002187542 cites W2098045183 @default.
• W2002187542 cites W2102461244 @default.
• W2002187542 cites W2102666223 @default.
• W2002187542 cites W2106042714 @default.
• W2002187542 cites W2127300695 @default.
• W2002187542 cites W2139679033 @default.
• W2002187542 cites W2141515004 @default.
• W2002187542 cites W2145636174 @default.
• W2002187542 cites W2149086984 @default.
• W2002187542 cites W2152328223 @default.
• W2002187542 cites W2742860702 @default.
• W2002187542 doi "https://doi.org/10.1074/jbc.m110.176966" @default.
• W2002187542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3003341" @default.
• W2002187542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20940295" @default.
• W2002187542 hasPublicationYear "2010" @default.
• W2002187542 type Work @default.
• W2002187542 sameAs 2002187542 @default.
• W2002187542 citedByCount "12" @default.
• W2002187542 countsByYear W20021875422014 @default.
• W2002187542 countsByYear W20021875422016 @default.
• W2002187542 countsByYear W20021875422018 @default.
• W2002187542 countsByYear W20021875422021 @default.
• W2002187542 crossrefType "journal-article" @default.
• W2002187542 hasAuthorship W2002187542A5002812144 @default.
• W2002187542 hasAuthorship W2002187542A5015095365 @default.
• W2002187542 hasAuthorship W2002187542A5028551018 @default.
• W2002187542 hasAuthorship W2002187542A5038383431 @default.
• W2002187542 hasAuthorship W2002187542A5085520556 @default.
• W2002187542 hasBestOaLocation W20021875421 @default.
• W2002187542 hasConcept C112592302 @default.
• W2002187542 hasConcept C126322002 @default.
• W2002187542 hasConcept C134018914 @default.
• W2002187542 hasConcept C169760540 @default.
• W2002187542 hasConcept C170493617 @default.
• W2002187542 hasConcept C17077164 @default.
• W2002187542 hasConcept C185592680 @default.
• W2002187542 hasConcept C200170125 @default.
• W2002187542 hasConcept C2775910092 @default.
• W2002187542 hasConcept C2776885963 @default.
• W2002187542 hasConcept C2778824757 @default.
• W2002187542 hasConcept C2778938600 @default.
• W2002187542 hasConcept C2780648746 @default.
• W2002187542 hasConcept C2780775167 @default.
• W2002187542 hasConcept C33789571 @default.
• W2002187542 hasConcept C61174792 @default.
• W2002187542 hasConcept C71924100 @default.
• W2002187542 hasConcept C86803240 @default.
• W2002187542 hasConceptScore W2002187542C112592302 @default.
• W2002187542 hasConceptScore W2002187542C126322002 @default.
• W2002187542 hasConceptScore W2002187542C134018914 @default.
• W2002187542 hasConceptScore W2002187542C169760540 @default.
• W2002187542 hasConceptScore W2002187542C170493617 @default.
• W2002187542 hasConceptScore W2002187542C17077164 @default.
• W2002187542 hasConceptScore W2002187542C185592680 @default.
• W2002187542 hasConceptScore W2002187542C200170125 @default.
• W2002187542 hasConceptScore W2002187542C2775910092 @default.
• W2002187542 hasConceptScore W2002187542C2776885963 @default.
• W2002187542 hasConceptScore W2002187542C2778824757 @default.
• W2002187542 hasConceptScore W2002187542C2778938600 @default.

• next