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- W2002187866 abstract "Quarante-deux sujets reçoivent avant tout mélange neuroleptanalgésiant 0,2 mg · kg−1 de midazolam I.V. Deux fois, une douleur à l'injection est signalée. La perte de la conversation survient en 38 ± 18 secondes et la perte du réflexe ciliaire en 75 ± 43 secondes. Au plan clinique, la seule modification cardiovasculaire significative constatée est une diminution de la pression artérielle systolique de 121,4 ± 19,5 mmHg à 114,8 ± 19,6 mmHg (p <0,005). Une apnée survient chez neuf patients (21 p. 100). Elle dure 29 ± 35 secondes. En régime ventilatoire stabilisé ni la ventilation minute, ni le volume courant, ni la fréquence respiratoire ne diffèrent significativement des chiffres de départ. En fin d'intervention, la réponse aux ordres simples est obtenue en 10 ± 13 minutes et l'orientation dans l'espace et dans le temps en 33 ± 28 minutes. L'amnésie du réveil est totale. L'examen de la veine utilisée ne montre aucun signe d'irritation veineuse jusqu'au troisième jour. Le midazolam se présente donc comme un agent hypnotique intéressant particulièrement chez les sujets fragiles. 42 patients are given, before any neuroleptanalgesia mixture, 0.2 mg · kg−1 of IV midazolam. Pain during the injection is reported in two cases. The loss of conversation onset is 38 ± 18 seconds and of the lid reflex is 75 ± 43 seconds. The only clinical variation is a drop of the systolic blood pressure from 121.4 ± 19.5 mmHg to 114.8 ± 19.6 mmHg, p <0.005. Apnea occurs in nine patients (21 per cent). It lasts 29 ± 35 seconds. But in a steady ventilatory state, the minute ventilation, the tidal volume and the respiratory rate are unchanged from the control values. At the end of the procedure, the answer to simple orders and the space and time orientation come back after 10 ± 13 minutes and 33 ± 28 minutes. The punctured vein is free of any reaction up to the third day. In conclusion, midazolam is a useful hypnotic drug mainly in the debilitated patient." @default.
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- W2002187866 date "1982-01-01" @default.
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- W2002187866 title "Le midazolam intraveineux comme agent hynotique d'une neuroleptanalgésie" @default.
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- W2002187866 doi "https://doi.org/10.1016/s0750-7658(82)80091-9" @default.
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