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• W2002188556 endingPage "130" @default.
• W2002188556 startingPage "119" @default.
• W2002188556 abstract "Endogenous opioid activity plays an important role in ethanol consumption and reinforcement in infant rats. Opioid systems are also involved in mediation and regulation of stress responses. Social isolation is a stressful experience for preweanling rats and changes the effects of ethanol through opioid-dependent mechanisms. The present study assessed effects of intracisternal (i.c.) administration of a selective mu-opioid antagonist (CTOP) and i.p. administration of a nonspecific opioid antagonist (naloxone) on voluntary intake and behavior in socially isolated 12-day-old (P12) pups treated with 0.5 g/kg ethanol. Voluntary intake of 0.1% saccharin or water, locomotion, rearing activity, paw licking and grooming were assessed during short-term isolation from littermates (STSI; 8-min duration). Thermal nociceptive reactivity was measured before and after this intake test, with normalized differences between pre- and post-test latencies of paw withdrawal from a hot plate (49°C) used as an index of isolation-induced analgesia (IIA). Results indicated several effects of social isolation and ethanol mediated through the mu-opioid system. Effects of low dose ethanol (0.5 g/kg) and voluntary consumption of saccharin interacted with endogenous mu-opioid activity associated with STSI. Blockade of mu-opioid receptors on saccharin consumption and paw licking-grooming affected intoxicated animals. Low dose ethanol and ingestion of saccharin blunted effects of CTOP on rearing behavior and nociceptive reactivity. Central injections of CTOP stimulated paw licking and grooming dependent on ethanol dose and type of fluid ingested. Ethanol selectively increased saccharin intake during STSI in females, naloxone and CTOP blocked ethanol-mediated enhancement of saccharin intake. We suggest that enhancement of saccharin intake by ethanol during STSI is the product of synergism between isolation-induced mu-opioid activity that increases the pup's sensitivity to appetitive taste stimulation and the anxiolytic effects of 0.5 g/kg ethanol that decreases behaviors otherwise competing with independent ingestive activity." @default.
• W2002188556 created "2016-06-24" @default.
• W2002188556 creator A5000943165 @default.
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• W2002188556 creator A5034025464 @default.
• W2002188556 creator A5063591341 @default.
• W2002188556 date "2014-03-01" @default.
• W2002188556 modified "2023-09-23" @default.
• W2002188556 title "Central effects of ethanol interact with endogenous mu-opioid activity to control isolation-induced analgesia in maternally separated infant rats" @default.
• W2002188556 cites W159844291 @default.
• W2002188556 cites W1760946711 @default.
• W2002188556 cites W1963501152 @default.
• W2002188556 cites W1963598417 @default.
• W2002188556 cites W1965605171 @default.
• W2002188556 cites W1972581570 @default.
• W2002188556 cites W1974488383 @default.
• W2002188556 cites W1975232919 @default.
• W2002188556 cites W1976011384 @default.
• W2002188556 cites W1977134170 @default.
• W2002188556 cites W1978125276 @default.
• W2002188556 cites W1978818986 @default.
• W2002188556 cites W1979133344 @default.
• W2002188556 cites W1984917106 @default.
• W2002188556 cites W1986274569 @default.
• W2002188556 cites W1990374871 @default.
• W2002188556 cites W1991882455 @default.
• W2002188556 cites W1993683854 @default.
• W2002188556 cites W1993999640 @default.
• W2002188556 cites W2004021068 @default.
• W2002188556 cites W2005072188 @default.
• W2002188556 cites W2005271935 @default.
• W2002188556 cites W2006218483 @default.
• W2002188556 cites W2007443280 @default.
• W2002188556 cites W2008218568 @default.
• W2002188556 cites W2009548083 @default.
• W2002188556 cites W2010818997 @default.
• W2002188556 cites W2011308569 @default.
• W2002188556 cites W2013504019 @default.
• W2002188556 cites W2015931222 @default.
• W2002188556 cites W2019553000 @default.
• W2002188556 cites W2020121706 @default.
• W2002188556 cites W2020640210 @default.
• W2002188556 cites W2021906777 @default.
• W2002188556 cites W2025192622 @default.
• W2002188556 cites W2029318834 @default.
• W2002188556 cites W2031547008 @default.
• W2002188556 cites W2032093960 @default.
• W2002188556 cites W2033500251 @default.
• W2002188556 cites W2035487697 @default.
• W2002188556 cites W2037204227 @default.
• W2002188556 cites W2037249096 @default.
• W2002188556 cites W2041512141 @default.
• W2002188556 cites W2043451851 @default.
• W2002188556 cites W2045851325 @default.
• W2002188556 cites W2045991542 @default.
• W2002188556 cites W2051363725 @default.
• W2002188556 cites W2054734270 @default.
• W2002188556 cites W2059244079 @default.
• W2002188556 cites W2059920772 @default.
• W2002188556 cites W2062106032 @default.
• W2002188556 cites W2064702605 @default.
• W2002188556 cites W2073674800 @default.
• W2002188556 cites W2076445235 @default.
• W2002188556 cites W2079086643 @default.
• W2002188556 cites W2081868024 @default.
• W2002188556 cites W2084586353 @default.
• W2002188556 cites W2084732070 @default.
• W2002188556 cites W2084979092 @default.
• W2002188556 cites W2085798404 @default.
• W2002188556 cites W2086800566 @default.
• W2002188556 cites W2087331621 @default.
• W2002188556 cites W2093870951 @default.
• W2002188556 cites W2098848290 @default.
• W2002188556 cites W2099201877 @default.
• W2002188556 cites W2100426967 @default.
• W2002188556 cites W2104084204 @default.
• W2002188556 cites W2104430900 @default.
• W2002188556 cites W2117212820 @default.
• W2002188556 cites W2117693696 @default.
• W2002188556 cites W2131466543 @default.
• W2002188556 cites W2137060882 @default.
• W2002188556 cites W2138932611 @default.
• W2002188556 cites W2146600835 @default.
• W2002188556 cites W2162042784 @default.
• W2002188556 cites W2167189322 @default.
• W2002188556 cites W2168864527 @default.
• W2002188556 cites W2169957480 @default.
• W2002188556 cites W4231695602 @default.
• W2002188556 cites W4236697038 @default.
• W2002188556 cites W4241100150 @default.
• W2002188556 cites W4242693468 @default.
• W2002188556 cites W4247283307 @default.
• W2002188556 cites W4247614553 @default.
• W2002188556 cites W2084187715 @default.
• W2002188556 doi "https://doi.org/10.1016/j.bbr.2013.11.043" @default.
• W2002188556 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3963276" @default.
• W2002188556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24315831" @default.

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