FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002189144> ?p ?o ?g. }

• W2002189144 endingPage "304" @default.
• W2002189144 startingPage "292" @default.
• W2002189144 abstract "The megencephaly mice show dramatic progressive increase in brain size and seizures. The overgrowth affects primarily the hippocampus and ventral cortex. The phenotype originates from a mutation in the Shaker-like voltage-gated potassium channel Kv1.1 brain, which results in a malfunctioning protein. A key question in elucidating the mechanism behind the unique brain overgrowth is whether it is caused by an increase in cell number. By applying stereological techniques, we found that the number of both neurons and astrocytes, as well as structure volume, was increased approximately two-fold within dentate gyrus (DG), CA2/3, and hilus of 12-week-old mceph/mceph versus wild type mice. In CA1, there was a tendency toward an increase in volume and in number of astrocytes. The volume estimates in newborn and p14 mice suggest that the overgrowth in mceph/mceph hippocampus starts between birth and the second week of life. To investigate the hyperplasia, cell proliferation was studied within the subgranular zone of the DG using BrdU and Ki67. There was a three-fold increase in proliferation in mceph/mceph mice compared to wild type mice at an age before onset of epileptic symptoms (3 weeks), and these new mceph/mceph neurons showed increased migration and had a 6-week survival rate as the new neurons in wild type DG. Also when seizures were frequent in mceph/mceph (9 weeks old), the proliferation rate was three-fold higher than in wild type. The number of TUNEL-positive cells in hippocampus was lower in mceph/mceph supporting additional overgrowth mechanism than induced by seizures. In conclusion, lack of a functional Kv1.1 ion channel subunit in the mceph/mceph mice causes a unique neuronal hyperplasia in distinct hippocampal regions and consequently hippocampal enlargement from 2 to 3 weeks of age. This phenotype is a result, at least in DG, from increased proliferation, neurogenesis, and enhanced general hippocampal cell survival." @default.
• W2002189144 created "2016-06-24" @default.
• W2002189144 creator A5033337407 @default.
• W2002189144 creator A5039084496 @default.
• W2002189144 creator A5053995530 @default.
• W2002189144 creator A5060982659 @default.
• W2002189144 creator A5062065720 @default.
• W2002189144 creator A5073633687 @default.
• W2002189144 creator A5075919129 @default.
• W2002189144 date "2007-01-01" @default.
• W2002189144 modified "2023-10-03" @default.
• W2002189144 title "Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargement" @default.
• W2002189144 cites W1533790491 @default.
• W2002189144 cites W1538710542 @default.
• W2002189144 cites W1540436551 @default.
• W2002189144 cites W1593725384 @default.
• W2002189144 cites W1777367897 @default.
• W2002189144 cites W1963730891 @default.
• W2002189144 cites W1966067258 @default.
• W2002189144 cites W1979612418 @default.
• W2002189144 cites W1980499453 @default.
• W2002189144 cites W1983955843 @default.
• W2002189144 cites W1994890528 @default.
• W2002189144 cites W2000883765 @default.
• W2002189144 cites W2008357800 @default.
• W2002189144 cites W2009027950 @default.
• W2002189144 cites W2010395737 @default.
• W2002189144 cites W2019970707 @default.
• W2002189144 cites W2026082008 @default.
• W2002189144 cites W2037367554 @default.
• W2002189144 cites W2042154782 @default.
• W2002189144 cites W2044103334 @default.
• W2002189144 cites W2048483736 @default.
• W2002189144 cites W2051021067 @default.
• W2002189144 cites W2060506587 @default.
• W2002189144 cites W2088233868 @default.
• W2002189144 cites W2105086774 @default.
• W2002189144 cites W2105382539 @default.
• W2002189144 cites W2109195226 @default.
• W2002189144 cites W2109416699 @default.
• W2002189144 cites W2126116200 @default.
• W2002189144 cites W2141568187 @default.
• W2002189144 cites W2146500000 @default.
• W2002189144 cites W2150936467 @default.
• W2002189144 cites W2387856814 @default.
• W2002189144 cites W4253449373 @default.
• W2002189144 doi "https://doi.org/10.1002/hipo.20268" @default.
• W2002189144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17315199" @default.
• W2002189144 hasPublicationYear "2007" @default.
• W2002189144 type Work @default.
• W2002189144 sameAs 2002189144 @default.
• W2002189144 citedByCount "20" @default.
• W2002189144 countsByYear W20021891442012 @default.
• W2002189144 countsByYear W20021891442013 @default.
• W2002189144 countsByYear W20021891442019 @default.
• W2002189144 countsByYear W20021891442021 @default.
• W2002189144 countsByYear W20021891442022 @default.
• W2002189144 crossrefType "journal-article" @default.
• W2002189144 hasAuthorship W2002189144A5033337407 @default.
• W2002189144 hasAuthorship W2002189144A5039084496 @default.
• W2002189144 hasAuthorship W2002189144A5053995530 @default.
• W2002189144 hasAuthorship W2002189144A5060982659 @default.
• W2002189144 hasAuthorship W2002189144A5062065720 @default.
• W2002189144 hasAuthorship W2002189144A5073633687 @default.
• W2002189144 hasAuthorship W2002189144A5075919129 @default.
• W2002189144 hasConcept C104317684 @default.
• W2002189144 hasConcept C126322002 @default.
• W2002189144 hasConcept C134018914 @default.
• W2002189144 hasConcept C136834591 @default.
• W2002189144 hasConcept C143065580 @default.
• W2002189144 hasConcept C148762608 @default.
• W2002189144 hasConcept C169760540 @default.
• W2002189144 hasConcept C185592680 @default.
• W2002189144 hasConcept C207583985 @default.
• W2002189144 hasConcept C2776464000 @default.
• W2002189144 hasConcept C2777542384 @default.
• W2002189144 hasConcept C2778794669 @default.
• W2002189144 hasConcept C2781161787 @default.
• W2002189144 hasConcept C2781176699 @default.
• W2002189144 hasConcept C28328180 @default.
• W2002189144 hasConcept C4746552 @default.
• W2002189144 hasConcept C54355233 @default.
• W2002189144 hasConcept C71924100 @default.
• W2002189144 hasConcept C83743174 @default.
• W2002189144 hasConcept C86803240 @default.
• W2002189144 hasConcept C95444343 @default.
• W2002189144 hasConceptScore W2002189144C104317684 @default.
• W2002189144 hasConceptScore W2002189144C126322002 @default.
• W2002189144 hasConceptScore W2002189144C134018914 @default.
• W2002189144 hasConceptScore W2002189144C136834591 @default.
• W2002189144 hasConceptScore W2002189144C143065580 @default.
• W2002189144 hasConceptScore W2002189144C148762608 @default.
• W2002189144 hasConceptScore W2002189144C169760540 @default.
• W2002189144 hasConceptScore W2002189144C185592680 @default.
• W2002189144 hasConceptScore W2002189144C207583985 @default.
• W2002189144 hasConceptScore W2002189144C2776464000 @default.
• W2002189144 hasConceptScore W2002189144C2777542384 @default.
• W2002189144 hasConceptScore W2002189144C2778794669 @default.

• next