FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002190789> ?p ?o ?g. }

• W2002190789 endingPage "811" @default.
• W2002190789 startingPage "802" @default.
• W2002190789 abstract "<i>Background/Aims:</i> Several pathways contribute to mechanisms by which ethanol induces oxidant stress. While some studies support a role for cytochrome P450 2E1 (CYP2E1), others do not. There is a need to develop oral models of significant ethanol-induced liver injury and to evaluate the possible role of CYP2E1 in ethanol actions in such models. <i>Methods:</i> We evaluated chronic ethanol-induced liver injury, steatosis and oxidant stress in wild-type (WT) mice, CYP2E1 knockout (KO) mice and in humanized CYP2E1 knockin (KI) mice, where the human 2E1 was added back to mice deficient in the mouse 2E1. WT mice and CYP2E1 KO and KI mice (both provided by Dr. F. Gonzalez, NCI) were fed a high-fat Lieber-DeCarli liquid diet for 3 weeks; pair-fed controls received dextrose. <i>Results:</i> Ethanol produced fatty liver and oxidant stress in WT mice, but liver injury (transaminases, histopathology) was minimal. Ethanol-induced steatosis and oxidant stress were blunted in the KO mice (no liver injury) but restored in the KI mice. Significant liver injury was produced in the ethanol-fed KI mice with elevated transaminases and necrosis. This liver injury in the KI mice was associated with elevated oxidant stress and elevated levels of the human CYP2E1 compared to levels of the mouse 2E1 in WT mice. Activation of JNK was observed in the ethanol-fed KI mice compared to the other groups. Fatty liver in WT and KI mice was associated with lower levels of lipolytic PPAR-α. No such changes were found in the ethanol-fed KO mice. <i>Conclusions:</i> These results show that CYP2E1 plays a major role in ethanol-induced fatty liver and oxidant stress. Restoring CYP2E1 in the CYP2E1 KO mice restores ethanol-induced fatty liver and oxidant stress." @default.
• W2002190789 created "2016-06-24" @default.
• W2002190789 creator A5046167919 @default.
• W2002190789 date "2010-01-01" @default.
• W2002190789 modified "2023-10-17" @default.
• W2002190789 title "Role of CYP2E1 in Ethanol-Induced Oxidant Stress, Fatty Liver and Hepatotoxicity" @default.
• W2002190789 cites W1491137382 @default.
• W2002190789 cites W1539472548 @default.
• W2002190789 cites W1543558763 @default.
• W2002190789 cites W1578466218 @default.
• W2002190789 cites W1616614392 @default.
• W2002190789 cites W1832164153 @default.
• W2002190789 cites W1902364422 @default.
• W2002190789 cites W1902476450 @default.
• W2002190789 cites W1967251260 @default.
• W2002190789 cites W1969677255 @default.
• W2002190789 cites W1971047268 @default.
• W2002190789 cites W1975192528 @default.
• W2002190789 cites W1981245425 @default.
• W2002190789 cites W1990413063 @default.
• W2002190789 cites W1992058399 @default.
• W2002190789 cites W1997037955 @default.
• W2002190789 cites W2009914744 @default.
• W2002190789 cites W2013161374 @default.
• W2002190789 cites W2017421642 @default.
• W2002190789 cites W2020778772 @default.
• W2002190789 cites W2021707548 @default.
• W2002190789 cites W2022763702 @default.
• W2002190789 cites W2029114762 @default.
• W2002190789 cites W2033522281 @default.
• W2002190789 cites W2033689665 @default.
• W2002190789 cites W2034717859 @default.
• W2002190789 cites W2040552715 @default.
• W2002190789 cites W2041729389 @default.
• W2002190789 cites W2046188137 @default.
• W2002190789 cites W2048278498 @default.
• W2002190789 cites W2049122420 @default.
• W2002190789 cites W2051096835 @default.
• W2002190789 cites W2053026149 @default.
• W2002190789 cites W2053897655 @default.
• W2002190789 cites W2055020668 @default.
• W2002190789 cites W2055620922 @default.
• W2002190789 cites W2058709707 @default.
• W2002190789 cites W2058843590 @default.
• W2002190789 cites W2060452153 @default.
• W2002190789 cites W2061361002 @default.
• W2002190789 cites W2062398703 @default.
• W2002190789 cites W2066238144 @default.
• W2002190789 cites W2068396499 @default.
• W2002190789 cites W2068520436 @default.
• W2002190789 cites W2072244763 @default.
• W2002190789 cites W2077418109 @default.
• W2002190789 cites W2083152621 @default.
• W2002190789 cites W2093289889 @default.
• W2002190789 cites W2093431528 @default.
• W2002190789 cites W2096627428 @default.
• W2002190789 cites W2096764074 @default.
• W2002190789 cites W2101982676 @default.
• W2002190789 cites W2114111268 @default.
• W2002190789 cites W2117446864 @default.
• W2002190789 cites W2122998222 @default.
• W2002190789 cites W2123420560 @default.
• W2002190789 cites W2129787534 @default.
• W2002190789 cites W2130191536 @default.
• W2002190789 cites W2134184179 @default.
• W2002190789 cites W2135561373 @default.
• W2002190789 cites W2137577984 @default.
• W2002190789 cites W2138145189 @default.
• W2002190789 cites W2138738670 @default.
• W2002190789 cites W2142081783 @default.
• W2002190789 cites W2142349229 @default.
• W2002190789 cites W2149642592 @default.
• W2002190789 cites W2153023641 @default.
• W2002190789 cites W2160724854 @default.
• W2002190789 cites W2164794447 @default.
• W2002190789 cites W2166848521 @default.
• W2002190789 cites W2170321705 @default.
• W2002190789 cites W2171969276 @default.
• W2002190789 cites W2188733915 @default.
• W2002190789 cites W2257536788 @default.
• W2002190789 cites W2979216016 @default.
• W2002190789 doi "https://doi.org/10.1159/000324289" @default.
• W2002190789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3211519" @default.
• W2002190789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21525766" @default.
• W2002190789 hasPublicationYear "2010" @default.
• W2002190789 type Work @default.
• W2002190789 sameAs 2002190789 @default.
• W2002190789 citedByCount "108" @default.
• W2002190789 countsByYear W20021907892012 @default.
• W2002190789 countsByYear W20021907892013 @default.
• W2002190789 countsByYear W20021907892014 @default.
• W2002190789 countsByYear W20021907892015 @default.
• W2002190789 countsByYear W20021907892016 @default.
• W2002190789 countsByYear W20021907892017 @default.
• W2002190789 countsByYear W20021907892018 @default.
• W2002190789 countsByYear W20021907892019 @default.
• W2002190789 countsByYear W20021907892020 @default.
• W2002190789 countsByYear W20021907892021 @default.

• next