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- W2002192178 abstract "Abstract Endurance training improves cardiac function and protects against heart disease. The rodent intensity‐controlled running model replicates endurance exercise in humans and can be used to investigate molecular adaptations in the heart. Rats ( n = 6, 280 ± 3 g) performed exercise tests to measure their peak oxygen uptake ( $ { dot V} { O}_{ 2} { peak}$ ) and training was prescribed at 70–75% $ { dot V} { O}_{ 2} { peak}$ for 30 min, 4 days/wk. Hearts were isolated 4 h after a final $ { dot V} { O}_{ 2} { peak}$ test and left ventricle proteomes compared to weight‐matched control animals ( n = 6, 330 ± 2 g) using differential analysis of 2‐D gels. Proteins were identified by searching MS and MS/MS spectra against Swiss‐Prot using MASCOT (www.matrixscience.com). Average $ { dot V} { O}_{ 2} { peak}$ increased 23% ( p = 0.008) over the 6‐week regimen and 23 gel spots differed ( p <0.05) between exercised and control hearts. Expression of myofibrillar proteins ( e.g . α‐myosin heavy chain and cardiac α‐actin) and proteins associated with fatty acid metabolism ( e.g . heart fatty acid binding protein, acetyl coenzyme A dehydrogenase and mitochondrial thioesterase‐1) increased. In addition, this work discovered a novel increase in phosphorylation of heat shock protein 20 at serine 16. Previously this modification has been associated with improved cardiomyocyte contractility and protection against apoptosis." @default.
- W2002192178 created "2016-06-24" @default.
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- W2002192178 date "2008-12-30" @default.
- W2002192178 modified "2023-09-30" @default.
- W2002192178 title "Adaptation of the rat cardiac proteome in response to intensity-controlled endurance exercise" @default.
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- W2002192178 doi "https://doi.org/10.1002/pmic.200800268" @default.
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