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• W2002193947 abstract "Tumorigenesis results from events that impinge on a variety of collaborating metabolic pathways. To assess their role in this process, we utilized a cell-based assay to perform a high-throughput, chemical library screen. In so doing, we identified F16, a small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 belongs to a group of structurally similar molecules with a delocalized positive charge. The compound is accumulated in mitochondria of responsive cells, driven by the membrane potential, and it compromises their functional integrity. Mitochondrial hyperpolarization is a shared feature of many tumor cell lines, explaining the broad action spectrum of this novel delocalized lipophilic cation." @default.
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• W2002193947 date "2002-07-01" @default.
• W2002193947 modified "2023-10-07" @default.
• W2002193947 title "A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth" @default.
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• W2002193947 doi "https://doi.org/10.1016/s1535-6108(02)00082-x" @default.
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