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- W2002194276 abstract "Male and female weanling, Sprague-Dawley rats were fed synthetic fat-free (FF) or corn oil-containing diets for 3 weeks. The apparent Km and Vmax for the metabolism of ethylmorphine and hexobarbital were lower in washed hepatic microsomes from male rats fed a FF diet than in rats fed diets containing 3 or 10 per cent corn oil. The apparent Vmax for aniline hydroxylase was also depressed by feeding a FF diet to male rats, although aniline Km was not altered. Feeding a FF diet to female rats decreased Vmax for both hexobarbital oxidase and aniline hydroxylase, but the apparent Km for the substrates was not changed. Gas-liquid Chromatographie analysis of fatty acids derived from microsomal membranes revealed marked alterations in the relative content of fatty acids in response to FF feeding. Content of cytochrome P-450 was lower in both male and female rats fed a FF diet. Associated with the decreased cytochrome P-450 content were decreases in the ability of microsomes to bind aniline and hexobarbital. A qualitative change produced in cytochrome P-450 was indicated by a decrease in the ratio of ethyl isocyanide peak heights (455:430 nm) in microsomes from FF-fed rats." @default.
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- W2002194276 date "1972-11-01" @default.
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- W2002194276 title "Dietary fatty acid-induced alterations of hepatic microsomal drug metabolism" @default.
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- W2002194276 doi "https://doi.org/10.1016/0006-2952(72)90213-4" @default.
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