FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002196299> ?p ?o ?g. }

• W2002196299 endingPage "PL102" @default.
• W2002196299 startingPage "PL97" @default.
• W2002196299 abstract "The effect of a peptide leukotriene receptor antagonist ONO-1078 on the production of thromboxane (Tx) B2 induced by leukotriene (LT) D4 and antigen challenge was examined in guinea pig lungs. LTD4 (1-1,000 nM) induced a concentration-dependent production of TxB2 in non-sensitized guinea pig lungs and ovalbumin challenge (0.01-100 micrograms/ml) produced TxB2 and peptide leukotrienes in a concentration-dependent manner in ovalbumin-sensitized guinea pig lungs. ONO-1078 inhibited LTD4 (100 nM)-induced TxB2 production with the IC50 value of 0.24 microM. Furthermore, ONO-1078 inhibited antigen (10 micrograms/ml)-induced TxB2 production with the IC50 value of 0.14 microM without effect on the production of peptide leukotrienes. These results suggest that ONO-1078 may prevent the antigen-induced production of TxB2 through the blockade of the activation of receptors by endogenously generated peptide leukotrienes." @default.
• W2002196299 created "2016-06-24" @default.
• W2002196299 creator A5007085135 @default.
• W2002196299 creator A5012678201 @default.
• W2002196299 creator A5042751840 @default.
• W2002196299 creator A5049214205 @default.
• W2002196299 creator A5076238304 @default.
• W2002196299 date "1993-01-01" @default.
• W2002196299 modified "2023-09-24" @default.
• W2002196299 title "Inhibitory effect of a peptide leukotriene antagonist ONO-1078 on LTD4- and antigen-induced thromboxane B2 production in guinea pig lungs" @default.
• W2002196299 cites W1969555049 @default.
• W2002196299 cites W1998154354 @default.
• W2002196299 cites W2004351423 @default.
• W2002196299 cites W2005231194 @default.
• W2002196299 cites W2028836971 @default.
• W2002196299 cites W2031708460 @default.
• W2002196299 cites W2040391593 @default.
• W2002196299 cites W2044002416 @default.
• W2002196299 cites W2051656004 @default.
• W2002196299 cites W2057945870 @default.
• W2002196299 cites W2060319662 @default.
• W2002196299 cites W2064882938 @default.
• W2002196299 cites W2094611539 @default.
• W2002196299 cites W2410351840 @default.
• W2002196299 cites W2413910094 @default.
• W2002196299 doi "https://doi.org/10.1016/0024-3205(93)90201-d" @default.
• W2002196299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8445989" @default.
• W2002196299 hasPublicationYear "1993" @default.
• W2002196299 type Work @default.
• W2002196299 sameAs 2002196299 @default.
• W2002196299 citedByCount "9" @default.
• W2002196299 crossrefType "journal-article" @default.
• W2002196299 hasAuthorship W2002196299A5007085135 @default.
• W2002196299 hasAuthorship W2002196299A5012678201 @default.
• W2002196299 hasAuthorship W2002196299A5042751840 @default.
• W2002196299 hasAuthorship W2002196299A5049214205 @default.
• W2002196299 hasAuthorship W2002196299A5076238304 @default.
• W2002196299 hasConcept C126322002 @default.
• W2002196299 hasConcept C134018914 @default.
• W2002196299 hasConcept C147483822 @default.
• W2002196299 hasConcept C170493617 @default.
• W2002196299 hasConcept C185592680 @default.
• W2002196299 hasConcept C203014093 @default.
• W2002196299 hasConcept C2776042228 @default.
• W2002196299 hasConcept C2776452501 @default.
• W2002196299 hasConcept C2776785769 @default.
• W2002196299 hasConcept C2776885963 @default.
• W2002196299 hasConcept C2776946954 @default.
• W2002196299 hasConcept C2777242621 @default.
• W2002196299 hasConcept C2778815084 @default.
• W2002196299 hasConcept C2779281246 @default.
• W2002196299 hasConcept C2779543280 @default.
• W2002196299 hasConcept C2780212800 @default.
• W2002196299 hasConcept C2781024287 @default.
• W2002196299 hasConcept C2781080829 @default.
• W2002196299 hasConcept C55493867 @default.
• W2002196299 hasConcept C71924100 @default.
• W2002196299 hasConcept C86803240 @default.
• W2002196299 hasConcept C89560881 @default.
• W2002196299 hasConceptScore W2002196299C126322002 @default.
• W2002196299 hasConceptScore W2002196299C134018914 @default.
• W2002196299 hasConceptScore W2002196299C147483822 @default.
• W2002196299 hasConceptScore W2002196299C170493617 @default.
• W2002196299 hasConceptScore W2002196299C185592680 @default.
• W2002196299 hasConceptScore W2002196299C203014093 @default.
• W2002196299 hasConceptScore W2002196299C2776042228 @default.
• W2002196299 hasConceptScore W2002196299C2776452501 @default.
• W2002196299 hasConceptScore W2002196299C2776785769 @default.
• W2002196299 hasConceptScore W2002196299C2776885963 @default.
• W2002196299 hasConceptScore W2002196299C2776946954 @default.
• W2002196299 hasConceptScore W2002196299C2777242621 @default.
• W2002196299 hasConceptScore W2002196299C2778815084 @default.
• W2002196299 hasConceptScore W2002196299C2779281246 @default.
• W2002196299 hasConceptScore W2002196299C2779543280 @default.
• W2002196299 hasConceptScore W2002196299C2780212800 @default.
• W2002196299 hasConceptScore W2002196299C2781024287 @default.
• W2002196299 hasConceptScore W2002196299C2781080829 @default.
• W2002196299 hasConceptScore W2002196299C55493867 @default.
• W2002196299 hasConceptScore W2002196299C71924100 @default.
• W2002196299 hasConceptScore W2002196299C86803240 @default.
• W2002196299 hasConceptScore W2002196299C89560881 @default.
• W2002196299 hasIssue "12" @default.
• W2002196299 hasLocation W20021962991 @default.
• W2002196299 hasLocation W20021962992 @default.
• W2002196299 hasOpenAccess W2002196299 @default.
• W2002196299 hasPrimaryLocation W20021962991 @default.
• W2002196299 hasRelatedWork W1775467750 @default.
• W2002196299 hasRelatedWork W1854206645 @default.
• W2002196299 hasRelatedWork W2002196299 @default.
• W2002196299 hasRelatedWork W2010303972 @default.
• W2002196299 hasRelatedWork W2054040671 @default.
• W2002196299 hasRelatedWork W2064339899 @default.
• W2002196299 hasRelatedWork W2072764216 @default.
• W2002196299 hasRelatedWork W2144831051 @default.
• W2002196299 hasRelatedWork W2394437567 @default.
• W2002196299 hasRelatedWork W2414643877 @default.
• W2002196299 hasVolume "52" @default.
• W2002196299 isParatext "false" @default.

• next