Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002199209> ?p ?o ?g. }
- W2002199209 endingPage "3641" @default.
- W2002199209 startingPage "3634" @default.
- W2002199209 abstract "Cervical cancer results from cervical infection by human papillomaviruses (HPV), especially HPV16. Previous studies have shown that intramuscular vaccination of women with an HPV16 virus-like particle (VLP) vaccine induced a strong IgG response and protected against genital HPV16 infection. However, an alternative route of administration that avoids parenteral injection while inducing mucosal immunity might facilitate vaccine implementation in some settings, and partially overcome the substantial variation in HPV16 antibodies at the cervix seen in ovulating women. In this study, women were vaccinated with escalating doses of HPV16L1 VLPs via nasal nebulisation, bronchial aerosolisation, or a combination of intramuscular and aerosol vaccination. The alternative routes of vaccination were well tolerated and many of the volunteers who received aerosol vaccinations exhibited serum antibody titers that were comparable to those induced by intramuscular vaccination. A mucosal immune response was induced by aerosol vaccination as demonstrated by the induction of anti-HPV16 VLP IgA secreting cells in PBMC and SIgA in secretions. Our data suggest that aerosol administration of HPV VLPs may represent a potential alternative to parenteral injection." @default.
- W2002199209 created "2016-06-24" @default.
- W2002199209 creator A5013756173 @default.
- W2002199209 creator A5018314969 @default.
- W2002199209 creator A5045427753 @default.
- W2002199209 creator A5075430537 @default.
- W2002199209 creator A5075591566 @default.
- W2002199209 creator A5076891332 @default.
- W2002199209 creator A5086386679 @default.
- W2002199209 creator A5086620768 @default.
- W2002199209 date "2005-05-25" @default.
- W2002199209 modified "2023-10-03" @default.
- W2002199209 title "Immune responses induced by lower airway mucosal immunisation with a human papillomavirus type 16 virus-like particle vaccine" @default.
- W2002199209 cites W1494328783 @default.
- W2002199209 cites W1548003848 @default.
- W2002199209 cites W1568972713 @default.
- W2002199209 cites W1577158615 @default.
- W2002199209 cites W1820208462 @default.
- W2002199209 cites W1874757117 @default.
- W2002199209 cites W1945561518 @default.
- W2002199209 cites W1963752586 @default.
- W2002199209 cites W1964749863 @default.
- W2002199209 cites W1987350137 @default.
- W2002199209 cites W1997287927 @default.
- W2002199209 cites W2001429203 @default.
- W2002199209 cites W2006414290 @default.
- W2002199209 cites W2007884263 @default.
- W2002199209 cites W2015402306 @default.
- W2002199209 cites W2022331203 @default.
- W2002199209 cites W2039742651 @default.
- W2002199209 cites W2065458595 @default.
- W2002199209 cites W2088457548 @default.
- W2002199209 cites W2093558460 @default.
- W2002199209 cites W2102925847 @default.
- W2002199209 cites W21119542 @default.
- W2002199209 cites W2114813165 @default.
- W2002199209 cites W2115914487 @default.
- W2002199209 cites W2117998062 @default.
- W2002199209 cites W2127913563 @default.
- W2002199209 cites W2137160891 @default.
- W2002199209 cites W2138786372 @default.
- W2002199209 cites W2139659516 @default.
- W2002199209 cites W2141696654 @default.
- W2002199209 cites W2142041681 @default.
- W2002199209 cites W2146360044 @default.
- W2002199209 cites W2146558740 @default.
- W2002199209 cites W2153444909 @default.
- W2002199209 cites W2154262967 @default.
- W2002199209 cites W2158399355 @default.
- W2002199209 cites W2158401973 @default.
- W2002199209 cites W2158415381 @default.
- W2002199209 cites W2158511077 @default.
- W2002199209 cites W2160874245 @default.
- W2002199209 cites W2162903981 @default.
- W2002199209 cites W2164835119 @default.
- W2002199209 cites W2165249729 @default.
- W2002199209 cites W2166978864 @default.
- W2002199209 cites W2167822747 @default.
- W2002199209 cites W2413089835 @default.
- W2002199209 cites W2464961741 @default.
- W2002199209 cites W3144581354 @default.
- W2002199209 doi "https://doi.org/10.1016/j.vaccine.2005.02.019" @default.
- W2002199209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15882523" @default.
- W2002199209 hasPublicationYear "2005" @default.
- W2002199209 type Work @default.
- W2002199209 sameAs 2002199209 @default.
- W2002199209 citedByCount "96" @default.
- W2002199209 countsByYear W20021992092012 @default.
- W2002199209 countsByYear W20021992092013 @default.
- W2002199209 countsByYear W20021992092014 @default.
- W2002199209 countsByYear W20021992092015 @default.
- W2002199209 countsByYear W20021992092016 @default.
- W2002199209 countsByYear W20021992092017 @default.
- W2002199209 countsByYear W20021992092018 @default.
- W2002199209 countsByYear W20021992092019 @default.
- W2002199209 countsByYear W20021992092021 @default.
- W2002199209 countsByYear W20021992092022 @default.
- W2002199209 countsByYear W20021992092023 @default.
- W2002199209 crossrefType "journal-article" @default.
- W2002199209 hasAuthorship W2002199209A5013756173 @default.
- W2002199209 hasAuthorship W2002199209A5018314969 @default.
- W2002199209 hasAuthorship W2002199209A5045427753 @default.
- W2002199209 hasAuthorship W2002199209A5075430537 @default.
- W2002199209 hasAuthorship W2002199209A5075591566 @default.
- W2002199209 hasAuthorship W2002199209A5076891332 @default.
- W2002199209 hasAuthorship W2002199209A5086386679 @default.
- W2002199209 hasAuthorship W2002199209A5086620768 @default.
- W2002199209 hasConcept C104317684 @default.
- W2002199209 hasConcept C121608353 @default.
- W2002199209 hasConcept C126322002 @default.
- W2002199209 hasConcept C159047783 @default.
- W2002199209 hasConcept C159654299 @default.
- W2002199209 hasConcept C203014093 @default.
- W2002199209 hasConcept C22070199 @default.
- W2002199209 hasConcept C2522874641 @default.
- W2002199209 hasConcept C2776291583 @default.
- W2002199209 hasConcept C2776387124 @default.
- W2002199209 hasConcept C2777740455 @default.