Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002201401> ?p ?o ?g. }
- W2002201401 endingPage "506" @default.
- W2002201401 startingPage "497" @default.
- W2002201401 abstract "Cisplatin is a widely used antineoplastic agent; however, its major limitation is the development of dose-dependent nephrotoxicity whose precise mechanisms are poorly understood. Here we show not only that mitochondrial dysfunction is a feature of cisplatin nephrotoxicity, but also that targeted delivery of superoxide dismutase mimetics to mitochondria largely prevents the renal effects of cisplatin. Cisplatin induced renal oxidative stress, deterioration of mitochondrial structure and function, an intense inflammatory response, histopathological injury, and renal dysfunction. A single systemic dose of mitochondrially targeted antioxidants, MitoQ or Mito-CP, dose-dependently prevented cisplatin-induced renal dysfunction. Mito-CP also prevented mitochondrial injury and dysfunction, renal inflammation, and tubular injury and apoptosis. Despite being broadly renoprotective against cisplatin, Mito-CP did not diminish cisplatin's antineoplastic effect in a human bladder cancer cell line. Our results highlight the central role of mitochondrially generated oxidants in the pathogenesis of cisplatin nephrotoxicity. Because similar compounds seem to be safe in humans, mitochondrially targeted antioxidants may represent a novel therapeutic approach against cisplatin nephrotoxicity." @default.
- W2002201401 created "2016-06-24" @default.
- W2002201401 creator A5011165903 @default.
- W2002201401 creator A5020862089 @default.
- W2002201401 creator A5029640117 @default.
- W2002201401 creator A5038364840 @default.
- W2002201401 creator A5046765991 @default.
- W2002201401 creator A5052876785 @default.
- W2002201401 creator A5066740889 @default.
- W2002201401 creator A5069350582 @default.
- W2002201401 creator A5074185770 @default.
- W2002201401 creator A5078771244 @default.
- W2002201401 creator A5084119264 @default.
- W2002201401 creator A5089152409 @default.
- W2002201401 creator A5091144377 @default.
- W2002201401 date "2012-01-01" @default.
- W2002201401 modified "2023-10-17" @default.
- W2002201401 title "Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy" @default.
- W2002201401 cites W17013332 @default.
- W2002201401 cites W1965436414 @default.
- W2002201401 cites W1966110021 @default.
- W2002201401 cites W1974693247 @default.
- W2002201401 cites W1976454725 @default.
- W2002201401 cites W1982330633 @default.
- W2002201401 cites W1983965827 @default.
- W2002201401 cites W1994247632 @default.
- W2002201401 cites W2006605504 @default.
- W2002201401 cites W2015746497 @default.
- W2002201401 cites W2016318917 @default.
- W2002201401 cites W2018076136 @default.
- W2002201401 cites W2019316722 @default.
- W2002201401 cites W2021131539 @default.
- W2002201401 cites W2028773523 @default.
- W2002201401 cites W2046136537 @default.
- W2002201401 cites W2052025850 @default.
- W2002201401 cites W2061430098 @default.
- W2002201401 cites W2064176864 @default.
- W2002201401 cites W2073740291 @default.
- W2002201401 cites W2083426418 @default.
- W2002201401 cites W2089801438 @default.
- W2002201401 cites W2089817405 @default.
- W2002201401 cites W2094745968 @default.
- W2002201401 cites W2108352961 @default.
- W2002201401 cites W2109706424 @default.
- W2002201401 cites W2113471444 @default.
- W2002201401 cites W2116749308 @default.
- W2002201401 cites W2117521967 @default.
- W2002201401 cites W2122386753 @default.
- W2002201401 cites W2132834292 @default.
- W2002201401 cites W2133497102 @default.
- W2002201401 cites W2144055106 @default.
- W2002201401 cites W2150256712 @default.
- W2002201401 cites W2155978870 @default.
- W2002201401 cites W2159285342 @default.
- W2002201401 cites W2164391817 @default.
- W2002201401 cites W2168631974 @default.
- W2002201401 cites W4234000443 @default.
- W2002201401 cites W4240717991 @default.
- W2002201401 doi "https://doi.org/10.1016/j.freeradbiomed.2011.11.001" @default.
- W2002201401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3253235" @default.
- W2002201401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22120494" @default.
- W2002201401 hasPublicationYear "2012" @default.
- W2002201401 type Work @default.
- W2002201401 sameAs 2002201401 @default.
- W2002201401 citedByCount "178" @default.
- W2002201401 countsByYear W20022014012012 @default.
- W2002201401 countsByYear W20022014012013 @default.
- W2002201401 countsByYear W20022014012014 @default.
- W2002201401 countsByYear W20022014012015 @default.
- W2002201401 countsByYear W20022014012016 @default.
- W2002201401 countsByYear W20022014012017 @default.
- W2002201401 countsByYear W20022014012018 @default.
- W2002201401 countsByYear W20022014012019 @default.
- W2002201401 countsByYear W20022014012020 @default.
- W2002201401 countsByYear W20022014012021 @default.
- W2002201401 countsByYear W20022014012022 @default.
- W2002201401 countsByYear W20022014012023 @default.
- W2002201401 crossrefType "journal-article" @default.
- W2002201401 hasAuthorship W2002201401A5011165903 @default.
- W2002201401 hasAuthorship W2002201401A5020862089 @default.
- W2002201401 hasAuthorship W2002201401A5029640117 @default.
- W2002201401 hasAuthorship W2002201401A5038364840 @default.
- W2002201401 hasAuthorship W2002201401A5046765991 @default.
- W2002201401 hasAuthorship W2002201401A5052876785 @default.
- W2002201401 hasAuthorship W2002201401A5066740889 @default.
- W2002201401 hasAuthorship W2002201401A5069350582 @default.
- W2002201401 hasAuthorship W2002201401A5074185770 @default.
- W2002201401 hasAuthorship W2002201401A5078771244 @default.
- W2002201401 hasAuthorship W2002201401A5084119264 @default.
- W2002201401 hasAuthorship W2002201401A5089152409 @default.
- W2002201401 hasAuthorship W2002201401A5091144377 @default.
- W2002201401 hasBestOaLocation W20022014012 @default.
- W2002201401 hasConcept C126189478 @default.
- W2002201401 hasConcept C126322002 @default.
- W2002201401 hasConcept C134018914 @default.
- W2002201401 hasConcept C185592680 @default.
- W2002201401 hasConcept C190283241 @default.
- W2002201401 hasConcept C2776151105 @default.