FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002202335> ?p ?o ?g. }

• W2002202335 endingPage "16363" @default.
• W2002202335 startingPage "16362" @default.
• W2002202335 abstract "Cholesterol is an essential component of lateral domain formation in lipid bilayers. Experiments using structural analogues of cholesterol have revealed that slight changes to the steroid headgroup chemistry can lead to significantly different degrees of domain formation. For example, the seemingly slight modification to 4-cholesten-3beta-one changes the molecule from domain enhancing to domain inhibiting. To investigate the relationship between steroid headgroup structure and domain formation, we have performed a series of coarse-grain molecular dynamics simulations in which the hydrophobicity of the steroid headgroup is altered. We show that bilayers containing steroids with polar headgroups undergo lateral phase separation, with the steroids adopting the canonical, upright orientation. However, increasing the hydrophobicity of the steroid's headgroup dramatically changes the orientation of the molecule such that it lies at the center of the bilayer, perpendicular to the bilayer normal. As a fundamental consequence, we show that these steroids inhibit the formation of phase-separated domains in membranes." @default.
• W2002202335 created "2016-06-24" @default.
• W2002202335 creator A5005690158 @default.
• W2002202335 creator A5040320940 @default.
• W2002202335 date "2009-10-27" @default.
• W2002202335 modified "2023-10-18" @default.
• W2002202335 title "Inhibiting Lateral Domain Formation in Lipid Bilayers: Simulations of Alternative Steroid Headgroup Chemistries" @default.
• W2002202335 cites W1542159434 @default.
• W2002202335 cites W1564861448 @default.
• W2002202335 cites W1967711052 @default.
• W2002202335 cites W1970541648 @default.
• W2002202335 cites W1985009426 @default.
• W2002202335 cites W1991163803 @default.
• W2002202335 cites W1995786129 @default.
• W2002202335 cites W2007616467 @default.
• W2002202335 cites W2010265988 @default.
• W2002202335 cites W2023125175 @default.
• W2002202335 cites W2025300239 @default.
• W2002202335 cites W2043801488 @default.
• W2002202335 cites W2055800207 @default.
• W2002202335 cites W2057291641 @default.
• W2002202335 cites W2058901028 @default.
• W2002202335 cites W2060024360 @default.
• W2002202335 cites W2080263214 @default.
• W2002202335 cites W2081995805 @default.
• W2002202335 cites W2086821325 @default.
• W2002202335 cites W2089791519 @default.
• W2002202335 cites W2092880628 @default.
• W2002202335 cites W2102399834 @default.
• W2002202335 cites W2110852753 @default.
• W2002202335 cites W2119267663 @default.
• W2002202335 cites W2122042576 @default.
• W2002202335 cites W2122882997 @default.
• W2002202335 cites W2139214699 @default.
• W2002202335 cites W2170193142 @default.
• W2002202335 cites W82875452 @default.
• W2002202335 doi "https://doi.org/10.1021/ja9079258" @default.
• W2002202335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19860442" @default.
• W2002202335 hasPublicationYear "2009" @default.
• W2002202335 type Work @default.
• W2002202335 sameAs 2002202335 @default.
• W2002202335 citedByCount "19" @default.
• W2002202335 countsByYear W20022023352012 @default.
• W2002202335 countsByYear W20022023352013 @default.
• W2002202335 countsByYear W20022023352014 @default.
• W2002202335 countsByYear W20022023352016 @default.
• W2002202335 countsByYear W20022023352017 @default.
• W2002202335 countsByYear W20022023352018 @default.
• W2002202335 countsByYear W20022023352019 @default.
• W2002202335 countsByYear W20022023352020 @default.
• W2002202335 crossrefType "journal-article" @default.
• W2002202335 hasAuthorship W2002202335A5005690158 @default.
• W2002202335 hasAuthorship W2002202335A5040320940 @default.
• W2002202335 hasConcept C12554922 @default.
• W2002202335 hasConcept C147597530 @default.
• W2002202335 hasConcept C178790620 @default.
• W2002202335 hasConcept C185592680 @default.
• W2002202335 hasConcept C192157962 @default.
• W2002202335 hasConcept C2780902042 @default.
• W2002202335 hasConcept C32909587 @default.
• W2002202335 hasConcept C39944091 @default.
• W2002202335 hasConcept C41625074 @default.
• W2002202335 hasConcept C55493867 @default.
• W2002202335 hasConcept C59593255 @default.
• W2002202335 hasConcept C71240020 @default.
• W2002202335 hasConcept C71315377 @default.
• W2002202335 hasConcept C8010536 @default.
• W2002202335 hasConcept C86803240 @default.
• W2002202335 hasConceptScore W2002202335C12554922 @default.
• W2002202335 hasConceptScore W2002202335C147597530 @default.
• W2002202335 hasConceptScore W2002202335C178790620 @default.
• W2002202335 hasConceptScore W2002202335C185592680 @default.
• W2002202335 hasConceptScore W2002202335C192157962 @default.
• W2002202335 hasConceptScore W2002202335C2780902042 @default.
• W2002202335 hasConceptScore W2002202335C32909587 @default.
• W2002202335 hasConceptScore W2002202335C39944091 @default.
• W2002202335 hasConceptScore W2002202335C41625074 @default.
• W2002202335 hasConceptScore W2002202335C55493867 @default.
• W2002202335 hasConceptScore W2002202335C59593255 @default.
• W2002202335 hasConceptScore W2002202335C71240020 @default.
• W2002202335 hasConceptScore W2002202335C71315377 @default.
• W2002202335 hasConceptScore W2002202335C8010536 @default.
• W2002202335 hasConceptScore W2002202335C86803240 @default.
• W2002202335 hasIssue "45" @default.
• W2002202335 hasLocation W20022023351 @default.
• W2002202335 hasLocation W20022023352 @default.
• W2002202335 hasOpenAccess W2002202335 @default.
• W2002202335 hasPrimaryLocation W20022023351 @default.
• W2002202335 hasRelatedWork W2013928131 @default.
• W2002202335 hasRelatedWork W2020705112 @default.
• W2002202335 hasRelatedWork W2024914238 @default.
• W2002202335 hasRelatedWork W2071788034 @default.
• W2002202335 hasRelatedWork W2079235499 @default.
• W2002202335 hasRelatedWork W2093253502 @default.
• W2002202335 hasRelatedWork W2346848543 @default.
• W2002202335 hasRelatedWork W2604676471 @default.
• W2002202335 hasRelatedWork W2791260019 @default.
• W2002202335 hasRelatedWork W4214543292 @default.

• next