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• W2002203670 abstract "Background: The highest blood pressure and its complications are found in black people compared to white subjects. Enhanced vascular contractility, attenuated vasodilation, and higher creatine kinase (CK) activity are all reported to be involved in the pathogenesis. This study aimed to assess whether normotensive whites and blacks differ in vascular contractile responses. Methods: Consecutive white and black women < 50 years old, scheduled for elective abdominal operations were eligible for inclusion. Women with bleeding disorders, inflammatory disease, diabetes, malignant disease, and smokers were excluded. Sample size calculation was based on maximum vasoconstriction with KPSS-noradrenaline (10–5 M) as the main outcome, assuming a 30% (Sd 10 %) higher force in black people, needing least 5 patients in each group. As secondary outcomes, we studied passive and active tension-diameter relations, bradykinin (up to 10–6 M), and sodium nitroprusside (up to 10–4 M) -induced vasodilation using a Mulvany-Alpern myograph. Finally, we added dinitro-fluorobenzene (DNFB, up to 10–6 M), a specific irreversible CK inhibitor, to assess the CK mediated contribution to potassium-mediated vasoconstriction. Results: Of 101 patients 66 were eligible. Three out of 33 white women were hypertensive vs 21 of 33 (64%) black women (odds of being normotensive and black 0.10 [0.03to 0.33] as compared to whites). Five normotensive blacks and 6 normotensive whites fulfilled inclusion criteria for the vessel study. Maximal contraction induced by KSS with noradrenaline was similar in both ethnic groups (9.98 ± 2.51 vs 10.21 ± 2.39 mN, whites vs blacks. vasodilation responses to bradykinin and SNP. The CK inhibitor DNFB reduced the contractile response in resistance vessels to 10% in whites, as in earlier studies in white women, and to 12% in blacks (p > 0.05). Conclusion: Selected normotensive black patients have similar vascular reactivity and intravascular CK activity as normotensive whites. These findings are in line with our earlier findings in a population study that black subjects with relatively low CK have lower blood pressures." @default.
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• W2002203670 date "2010-06-01" @default.
• W2002203670 modified "2023-09-26" @default.
• W2002203670 title "CONTRACTILITY OF ISOLATED RESISTANCE ARTERIES IN NORMOTENSIVE BLACK AND WHITE WOMEN: PP.11.440" @default.
• W2002203670 doi "https://doi.org/10.1097/01.hjh.0000378765.24347.60" @default.
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