FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002207905> ?p ?o ?g. }

• W2002207905 endingPage "58" @default.
• W2002207905 startingPage "45" @default.
• W2002207905 abstract "The urinary and fecal distribution and the relative proportions of the four coproporphyrin (copro) isomers I-IV were analysed in 20 healthy subjects and in patients suffering from one of the seven common types of hepatic or erythropoietic hereditary porphyrias. The ratios of copro isomers I-IV were analyzed by ion-pair high-performance liquid chromatography (HPLC). Observations showed significantly increased proportions of fecal copro isomer I and decreased proportions of copro isomers III, II and IV in erythropoietic porphyrias. In acute hepatic porphyrias the excretion of fecal copro isomer III is dominant (isomer III = 58.4+/-24.0%; x+/-S.D.) and significantly higher (P < 0.001) than in erythropoietic porphyrias (isomer III = 15.3+/-7.7%; x+/-S.D.) and chronic hepatic porphyrias (isomer III = 25.8+/-7.6%; x+/-S.D.). The increased proportions of fecal copro isomer III proved to be important for the diagnosis of hereditary coproporphyria and porphyria variegata independent of the clinical phase existing. These last two acute hepatic porphyrias also showed markedly elevated percentages of the fecal atypical isomers II and IV. In urine significantly decreased proportions of copro isomer I in acute hepatic porphyrias (isomer I = 12.3+/-6.0%; x+/-S.D.) could be observed as compared with non-acute porphyrias (isomer I = 53.7+/-15.2%; x+/-S.D.). Conversely, the proportion of urinary copro isomer III was significantly higher in acute hepatic porphyrias (isomer III= 81.4+/-6.4%; x+/-S.D.). As expected, the greatest amounts of urinary copro isomer I were found in congenital erythropoietic porphyria (isomer I =92.0+/-3.3; x+/-S.D.) and protoporphyria with hepatobiliary complications (isomer I = 81.3+/-10.7; x+/-S.D.). The atypical urinary copro isomers I1 and IV were detected in all types of porphyrias ranging from 0.1 to 11.5%. The combined amounts of copro isomers II and IV show a significantly decreased percentage in congenital erythropoietic porphyria as compared with all other types of hereditary porphyrias. In conclusion, we demonstrate that the characteristic pattern of the copro isomer constellations I-IV in the various types of porphyrias are of differential diagnostic importance. The inversion of the I to III ratio in feces in hereditary coproporphyria and porphyria variegata allows the recognition of gene carriers." @default.
• W2002207905 created "2016-06-24" @default.
• W2002207905 creator A5006290629 @default.
• W2002207905 creator A5052604618 @default.
• W2002207905 creator A5062243111 @default.
• W2002207905 creator A5074748428 @default.
• W2002207905 date "1999-04-01" @default.
• W2002207905 modified "2023-10-14" @default.
• W2002207905 title "Studies on coproporphyrin isomers in urine and feces in the porphyrias" @default.
• W2002207905 cites W1983979256 @default.
• W2002207905 cites W1990401934 @default.
• W2002207905 cites W1999939101 @default.
• W2002207905 cites W2008281391 @default.
• W2002207905 cites W2012276057 @default.
• W2002207905 cites W2013795624 @default.
• W2002207905 cites W2020820511 @default.
• W2002207905 cites W2021228693 @default.
• W2002207905 cites W2029727742 @default.
• W2002207905 cites W2043113001 @default.
• W2002207905 cites W2067672720 @default.
• W2002207905 cites W2075944998 @default.
• W2002207905 cites W2093981017 @default.
• W2002207905 cites W2101143075 @default.
• W2002207905 cites W2140671637 @default.
• W2002207905 cites W2168886853 @default.
• W2002207905 cites W2412488756 @default.
• W2002207905 cites W4252329813 @default.
• W2002207905 doi "https://doi.org/10.1016/s0009-8981(99)00036-4" @default.
• W2002207905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10340433" @default.
• W2002207905 hasPublicationYear "1999" @default.
• W2002207905 type Work @default.
• W2002207905 sameAs 2002207905 @default.
• W2002207905 citedByCount "19" @default.
• W2002207905 countsByYear W20022079052019 @default.
• W2002207905 countsByYear W20022079052021 @default.
• W2002207905 countsByYear W20022079052022 @default.
• W2002207905 countsByYear W20022079052023 @default.
• W2002207905 crossrefType "journal-article" @default.
• W2002207905 hasAuthorship W2002207905A5006290629 @default.
• W2002207905 hasAuthorship W2002207905A5052604618 @default.
• W2002207905 hasAuthorship W2002207905A5062243111 @default.
• W2002207905 hasAuthorship W2002207905A5074748428 @default.
• W2002207905 hasConcept C10146269 @default.
• W2002207905 hasConcept C126322002 @default.
• W2002207905 hasConcept C134018914 @default.
• W2002207905 hasConcept C151730666 @default.
• W2002207905 hasConcept C185592680 @default.
• W2002207905 hasConcept C2780026642 @default.
• W2002207905 hasConcept C55493867 @default.
• W2002207905 hasConcept C61716771 @default.
• W2002207905 hasConcept C71924100 @default.
• W2002207905 hasConcept C77411442 @default.
• W2002207905 hasConcept C86803240 @default.
• W2002207905 hasConceptScore W2002207905C10146269 @default.
• W2002207905 hasConceptScore W2002207905C126322002 @default.
• W2002207905 hasConceptScore W2002207905C134018914 @default.
• W2002207905 hasConceptScore W2002207905C151730666 @default.
• W2002207905 hasConceptScore W2002207905C185592680 @default.
• W2002207905 hasConceptScore W2002207905C2780026642 @default.
• W2002207905 hasConceptScore W2002207905C55493867 @default.
• W2002207905 hasConceptScore W2002207905C61716771 @default.
• W2002207905 hasConceptScore W2002207905C71924100 @default.
• W2002207905 hasConceptScore W2002207905C77411442 @default.
• W2002207905 hasConceptScore W2002207905C86803240 @default.
• W2002207905 hasIssue "1-2" @default.
• W2002207905 hasLocation W20022079051 @default.
• W2002207905 hasLocation W20022079052 @default.
• W2002207905 hasOpenAccess W2002207905 @default.
• W2002207905 hasPrimaryLocation W20022079051 @default.
• W2002207905 hasRelatedWork W1591989182 @default.
• W2002207905 hasRelatedWork W1989043854 @default.
• W2002207905 hasRelatedWork W2027850379 @default.
• W2002207905 hasRelatedWork W261602365 @default.
• W2002207905 hasRelatedWork W2748952813 @default.
• W2002207905 hasRelatedWork W2950569979 @default.
• W2002207905 hasRelatedWork W2971700887 @default.
• W2002207905 hasRelatedWork W3213079831 @default.
• W2002207905 hasRelatedWork W4205289363 @default.
• W2002207905 hasRelatedWork W4207026437 @default.
• W2002207905 hasVolume "282" @default.
• W2002207905 isParatext "false" @default.
• W2002207905 isRetracted "false" @default.
• W2002207905 magId "2002207905" @default.
• W2002207905 workType "article" @default.