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- W2002208033 abstract "Abstract In vitro release kinetics of structurally related benzoic acids and other active ingredients from glassy hydrogels are reported. It is shown that a zero-order release from swellable glassy poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels can be achieved by a judicious choice of the active ingredient. The criteria for the swelling controlled zero-order release proposed in the past have been examined. The equilibrium swelling interface number (Swe) is a rather conservative criterion. It is shown that swelling controlled zero-order release can be realized for values of the swelling interface number up to 0.6. The Deborah numbers for release (DeR) for the systems which follow zero-order kinetics are in good agreement with the predictions based on the time dependent diffusion coefficient to account for the role of the molecular relaxation processes." @default.
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- W2002208033 title "Zero-order release from glassy hydrogels. I. Enigma of the swelling interface number" @default.
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- W2002208033 doi "https://doi.org/10.1016/s0376-7388(00)80787-5" @default.
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