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• W2002209503 abstract "ABSTRACT Protease‐activated receptor‐2 (PAR‐2) is a G‐protein‐coupled receptor activated through proteolytic cleavage. It is localized on epithelial, endothelial and inflammatory cells, as well as on transient receptor potential vanilloid 1 (TRPV1) receptor‐expressing neurones. It plays an important role in inflammatory/nociceptive processes. Since there are few reports concerning PAR‐2 function in joints, the effects of intraarticular PAR‐2 activation on joint pain and inflammation were studied. Secondary hyperalgesia/allodynia, spontaneous weight distribution, swelling and inflammatory cytokine production were measured and the involvement of TRPV1 ion channels was investigated in rats and mice. Injection of the PAR‐2 receptor agonist SLIGRL‐NH 2 into the knee decreased touch sensitivity and weight bearing of the ipsilateral hindlimb in both species. Secondary mechanical allodynia/hyperalgesia and impaired weight distribution were significantly reduced by the TRPV1 antagonist SB366791 in rats and by the genetic deletion of this receptor in mice. PAR‐2 activation did not cause significant joint swelling, but increased IL‐1β concentration which was not influenced by the lack of the TRPV1 channel. For comparison, intraplantar SLIGRL‐NH 2 evoked similar primary mechanical hyperalgesia and impaired weight distribution in both WT and TRPV1 deficient mice, but oedema was smaller in the knockouts. The inactive peptide, LRGILS‐NH 2 , injected into either site did not induce any inflammatory or nociceptive changes. These data provide evidence for a significant role of TRPV1 receptors in secondary mechanical hyperalgesia/allodynia and spontaneous pain induced by PAR‐2 receptor activation in the knee joint. Although intraplantar PAR‐2 activation‐induced oedema is also TRPV1 receptor‐mediated, primary mechanical hyperalgesia, impaired weight distribution and IL‐1β production are independent of this channel." @default.
• W2002209503 created "2016-06-24" @default.
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• W2002209503 date "2010-04-01" @default.
• W2002209503 modified "2023-10-18" @default.
• W2002209503 title "Involvement of transient receptor potential vanilloid 1 receptors in protease-activated receptor-2-induced joint inflammation and nociception" @default.
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• W2002209503 doi "https://doi.org/10.1016/j.ejpain.2009.07.005" @default.
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