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- W2002209637 abstract "A 2-year-old boy presented with anaemia, thrombocytopenia and splenomegaly. He had circulating blasts, 5 × 109/l, approximately 25% of which resembled L3 (Burkitt-type) cells (top left). However, a bone marrow aspirate showed replacement with predominantly small lymphoblasts with L1 morphology (top right), only 5% with L3 features (middle left). The blasts expressed terminal deoxynucleotidyl transferase, CD19, CD10 and HLA DR, but not surface immunoglobulin. Standard treatment for acute lymphoblastic leukaemia was instituted. Cytogenetic analysis of marrow showed 47, XY, t(8;22)(q24;q11), + 21 in 8 out of 10 metaphases analysed; two had a normal karyotype. Fluorescence in situ hybridization (FISH) using a two-colour probe for MYC showed a normal fused signal on one chromosome 8 but separate signals on der(8) (red) and der(22) (green), confirming involvement of MYC in the translocation; splitting of the MYC signal was also seen in interphase nuclei (middle right). These FISH findings corroborated the conventional chromosome analysis (partial karyotype is shown in lower image) in identifying the typical t(8;22) of Burkitt's lymphoma. Despite absence of the usual immunophenotypic features, the cytogenetic findings coupled with the morphological features of a minority of the blasts were persuasive enough to warrant changing the diagnosis. Treatment was altered to the current United Kingdom Children's Cancer Study Group regimen for mature B-cell non-Hodgkin's lymphoma, FAB LMB 96. Complete remission persists, at the time of writing, 23 months after presentation." @default.
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- W2002209637 date "2003-08-21" @default.
- W2002209637 modified "2023-10-17" @default.
- W2002209637 title "Surface immunoglobulin-negative acute lymphoblastic leukaemia with predominant L1 morphology, occasional L3 cells and t(8;22)" @default.
- W2002209637 doi "https://doi.org/10.1046/j.1365-2141.2003.04407.x" @default.
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