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• W2002221161 abstract "Oligo(2'-O-alkylribonucleotides) have been developed recently as novel oligonucleotide analogues with properties that enhance their use as antisense probes. They possess high chemical stability and are resistant to hydrolysis by DNA- or RNA-specific nucleases. Many forms of oligo(2'-O-alkylribonucleotides) hybridise specifically and efficiently to complementary RNA sequences, forming stable duplexes that are not substrates for cleavage by RNAse H. In combination with prosthetic reporter groups, such as biotin, DNP or fluorophores, oligo(2'-O-alkylribonucleotides) have important applications in a wide range of biochemical studies on RNA function and structure." @default.
• W2002221161 created "2016-06-24" @default.
• W2002221161 creator A5014112981 @default.
• W2002221161 creator A5083010445 @default.
• W2002221161 date "1993-06-28" @default.
• W2002221161 modified "2023-09-24" @default.
• W2002221161 title "Antisense oligonucleotides made of 2'-<i>O</i>-alkylRNA: their properties and applications in RNA biochemistry" @default.
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• W2002221161 doi "https://doi.org/10.1016/0014-5793(93)81427-2" @default.
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