FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002233878> ?p ?o ?g. }

• W2002233878 endingPage "336" @default.
• W2002233878 startingPage "331" @default.
• W2002233878 abstract "Glial cell line-derived neurotrophic factor (GDNF), a powerful trophic factor for developing, and injured adult motor neurons, has recently been shown to mediate its physiological effects via a multi-component receptor system comprising the GDNFR-alpha binding protein and the c-ret receptor tyrosine kinase. Using in situ hybridization histochemistry this study investigated whether adult motor neurons express mRNAs encoding GDNFR-alpha and c-ret, and explored possible time-dependent changes in these mRNA species following facial nerve resection and crush injury. Levels of mRNA for the signaling component of the GDNF receptor, c-ret, were increased approximately 1.4-fold in the ipsilateral facial nucleus, 1 and 3 days after unilateral facial nerve crush and resection, but returned to contralateral levels by 7-21 days. GDNFR-alpha mRNA was increased from 2 to 3-fold in the facial nucleus at 1 and 3 days after facial nerve crush and to similar, but more sustained (up to 21 days), levels after resection. In contrast, GDNF mRNA was not detectable in normal or injured facial motor neurons. The gradual return of c-ret and GDNFR-alpha mRNAs to control levels 21 days after facial nerve crush, parallels the axonal regeneration process, while nerve damage by resection has more severe consequences compared to nerve crush, reflected by the prolonged time course of increased GDNFR-alpha mRNA, similar to markers such as the NGF-receptor, galanin and GAP-43. These findings confirm the importance of GDNF trophic/signaling systems after nerve injury and suggest the potential for broad biological and therapeutic actions of GDNF or related factors in the CNS, particularly on damaged motor neurons." @default.
• W2002233878 created "2016-06-24" @default.
• W2002233878 creator A5021467089 @default.
• W2002233878 creator A5076320411 @default.
• W2002233878 date "1998-04-01" @default.
• W2002233878 modified "2023-09-26" @default.
• W2002233878 title "Up-regulation of GDNFR-α and c-ret mRNA in facial motor neurons following facial nerve injury in the rat" @default.
• W2002233878 cites W1510857662 @default.
• W2002233878 cites W1578346366 @default.
• W2002233878 cites W1614532287 @default.
• W2002233878 cites W1967672185 @default.
• W2002233878 cites W1971644755 @default.
• W2002233878 cites W1976857475 @default.
• W2002233878 cites W1980756005 @default.
• W2002233878 cites W1991391868 @default.
• W2002233878 cites W1994452959 @default.
• W2002233878 cites W1998885927 @default.
• W2002233878 cites W2014078232 @default.
• W2002233878 cites W2017166426 @default.
• W2002233878 cites W2023563139 @default.
• W2002233878 cites W2028093783 @default.
• W2002233878 cites W2032985825 @default.
• W2002233878 cites W2036834043 @default.
• W2002233878 cites W2054810445 @default.
• W2002233878 cites W2069210581 @default.
• W2002233878 cites W2087262420 @default.
• W2002233878 cites W2087759355 @default.
• W2002233878 cites W2108737605 @default.
• W2002233878 cites W2111565211 @default.
• W2002233878 cites W2161704465 @default.
• W2002233878 doi "https://doi.org/10.1016/s0169-328x(98)00017-5" @default.
• W2002233878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9582449" @default.
• W2002233878 hasPublicationYear "1998" @default.
• W2002233878 type Work @default.
• W2002233878 sameAs 2002233878 @default.
• W2002233878 citedByCount "34" @default.
• W2002233878 countsByYear W20022338782012 @default.
• W2002233878 countsByYear W20022338782013 @default.
• W2002233878 countsByYear W20022338782015 @default.
• W2002233878 countsByYear W20022338782018 @default.
• W2002233878 countsByYear W20022338782020 @default.
• W2002233878 countsByYear W20022338782022 @default.
• W2002233878 countsByYear W20022338782023 @default.
• W2002233878 crossrefType "journal-article" @default.
• W2002233878 hasAuthorship W2002233878A5021467089 @default.
• W2002233878 hasAuthorship W2002233878A5076320411 @default.
• W2002233878 hasConcept C104317684 @default.
• W2002233878 hasConcept C105580179 @default.
• W2002233878 hasConcept C105702510 @default.
• W2002233878 hasConcept C126322002 @default.
• W2002233878 hasConcept C134018914 @default.
• W2002233878 hasConcept C141071460 @default.
• W2002233878 hasConcept C159167319 @default.
• W2002233878 hasConcept C160539049 @default.
• W2002233878 hasConcept C169760540 @default.
• W2002233878 hasConcept C170493617 @default.
• W2002233878 hasConcept C185856081 @default.
• W2002233878 hasConcept C2777107032 @default.
• W2002233878 hasConcept C2778987478 @default.
• W2002233878 hasConcept C2779683492 @default.
• W2002233878 hasConcept C513476851 @default.
• W2002233878 hasConcept C529278444 @default.
• W2002233878 hasConcept C55493867 @default.
• W2002233878 hasConcept C71924100 @default.
• W2002233878 hasConcept C81439078 @default.
• W2002233878 hasConcept C86803240 @default.
• W2002233878 hasConceptScore W2002233878C104317684 @default.
• W2002233878 hasConceptScore W2002233878C105580179 @default.
• W2002233878 hasConceptScore W2002233878C105702510 @default.
• W2002233878 hasConceptScore W2002233878C126322002 @default.
• W2002233878 hasConceptScore W2002233878C134018914 @default.
• W2002233878 hasConceptScore W2002233878C141071460 @default.
• W2002233878 hasConceptScore W2002233878C159167319 @default.
• W2002233878 hasConceptScore W2002233878C160539049 @default.
• W2002233878 hasConceptScore W2002233878C169760540 @default.
• W2002233878 hasConceptScore W2002233878C170493617 @default.
• W2002233878 hasConceptScore W2002233878C185856081 @default.
• W2002233878 hasConceptScore W2002233878C2777107032 @default.
• W2002233878 hasConceptScore W2002233878C2778987478 @default.
• W2002233878 hasConceptScore W2002233878C2779683492 @default.
• W2002233878 hasConceptScore W2002233878C513476851 @default.
• W2002233878 hasConceptScore W2002233878C529278444 @default.
• W2002233878 hasConceptScore W2002233878C55493867 @default.
• W2002233878 hasConceptScore W2002233878C71924100 @default.
• W2002233878 hasConceptScore W2002233878C81439078 @default.
• W2002233878 hasConceptScore W2002233878C86803240 @default.
• W2002233878 hasIssue "2" @default.
• W2002233878 hasLocation W20022338781 @default.
• W2002233878 hasLocation W20022338782 @default.
• W2002233878 hasOpenAccess W2002233878 @default.
• W2002233878 hasPrimaryLocation W20022338781 @default.
• W2002233878 hasRelatedWork W1991229350 @default.
• W2002233878 hasRelatedWork W2009920191 @default.
• W2002233878 hasRelatedWork W2017166426 @default.
• W2002233878 hasRelatedWork W2040676538 @default.
• W2002233878 hasRelatedWork W2051062618 @default.
• W2002233878 hasRelatedWork W2061846521 @default.
• W2002233878 hasRelatedWork W2071360006 @default.

• next