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- W2002236314 abstract "P-type Ca 2+ -transporting ATPases are Ca 2+ pumps, extruding cytosolic Ca 2+ to the extracellular environment or the intracellular Ca 2+ store lumens. In budding yeast, Pmr1 (plasma membrane ATPase related), and Pmc1 (plasma membrane calcium-ATPase) cannot be deleted simultaneously for it to survive in standard medium. Here, we deleted two putative Ca 2+ pumps, designated AnPmrA and AnPmcA, from Aspergillus nidulans , and obtained the mutants Δ anpmrA and Δ anpmcA , respectively. Then, using Δ anpmrA as the starting strain, the promoter of its anpmcA was replaced with the alcA promoter to secure the mutant Δ anpmrAalcApmcA or its anpmcA was deleted completely to produce the mutant Δ anpmrA Δ pmcA . Different from the case in Saccharomyces cerevisiae , double deletion of anpmrA and anpmcA was not lethal in A. nidulans . In addition, deletion of anpmrA and/or anpmcA had produced growth defects, although overexpression of AnPmc1 in Δ anpmrAalcApmcA could not restore the growth defects that resulted from the loss of AnPmrA. Moreover, we found AnPmrA was indispensable for maintenance of normal morphogenesis, especially in low-Ca 2+ /Mn 2+ environments. Thus, our findings suggest AnPmrA and AnPmcA might play important roles in growth, morphogenesis and cell wall integrity in A. nidulans in a different way from that in yeasts." @default.
- W2002236314 created "2016-06-24" @default.
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- W2002236314 date "2014-11-01" @default.
- W2002236314 modified "2023-10-17" @default.
- W2002236314 title "Putative PmrA and PmcA are important for normal growth, morphogenesis and cell wall integrity, but not for viability in Aspergillus nidulans" @default.
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- W2002236314 doi "https://doi.org/10.1099/mic.0.080119-0" @default.
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