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- W2002242515 abstract "Mild pyrolysis (228 °C, 15 min) of rosmarinic, chlorogenic, and caffeic acids increased their antioxidative efficacy in a biological rat liver membrane assay by 4-, 11-, and 460-fold, respectively. The active components in the caffeic acid pyrolysates were identified as the recently isolated novel tetraoxygenated 1,3-cis- and 1,3-trans-phenylindan isomers, which showed comparable IC50 values (0.041 and 0.04 μM, respectively) and were ∼8-fold more active than butylated hydroxytoluene (BHT). Comparison of nonroasted, light-roasted, and dark-roasted coffee extracts showed that the degree of roasting is positively correlated to the inhibition of lipid peroxidation in rat liver membranes. The potent reducing properties of the phenylindan isomers resulted in (a) prooxidative effects at relatively higher concentrations in an ethyl linoleate peroxidation assay, and (b) promotion of hydroxylation of 2‘-deoxyguanosine to afford 8-oxo-2‘-deoxyguanosine. However, the results of the rat liver homogenate model system show that pyrolysis of caffeic acid and its esters chlorogenic acid and rosmarinic acid can procure potent antioxidants and underlines the potential use of heat processing to generate novel bioactive molecules. Keywords: Caffeic acid; phenylindan isomers; antioxidants, prooxidants; polyphenols; lipid peroxidation" @default.
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- W2002242515 title "Antioxidant Properties of Novel Tetraoxygenated Phenylindan Isomers Formed during Thermal Decomposition of Caffeic Acid" @default.
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- W2002242515 doi "https://doi.org/10.1021/jf9508155" @default.
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