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• W2002243241 abstract "Abstract 3‐Nitro‐ and 3‐cyanopyrocatechols bearing electron‐withdrawing substituents at C(5) have been found to inhibit the enzyme catechol‐ O ‐methyltransferase. Structure‐activity studies are discussed on the basis of the pharmocological data of 50 compounds ( cf, Chapt. 4, Tables 1–7 ). Some 3‐nitro‐5‐aroylpyrocatechols ( Type A 2 , Table 1 ) fulfil the requirements for a clinical candidate, being orally active, specific, reversible, and relatively short‐acting. The chemical work involved is illustrated by describing a choice of exemplary syntheses, dealing with compounds 9, 11, 14, 18, 22, 24, 25, 35, 41 , and 42 (Chapt. 5, Schemes 1–10) ." @default.
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• W2002243241 date "1989-08-09" @default.
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• W2002243241 title "Catechol-<i>O</i>-methyltransferase-Inhibiting Pyrocatechol Derivatives: Synthesis and Structure-Activity Studies" @default.
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• W2002243241 doi "https://doi.org/10.1002/hlca.19890720511" @default.
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