FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002246590> ?p ?o ?g. }

• W2002246590 endingPage "251" @default.
• W2002246590 startingPage "239" @default.
• W2002246590 abstract "Photodynamic therapy (PDT) is a relatively new approach to the treatment of neoplasms which involves the use of photoactivatable compounds to selectively destroy tumors. 5-Aminolevulinic acid (ALA) is an endogenous substance which is converted to protoporphyrin IX (PpIX) in the synthetic pathway to heme. PpIX is a very effective photosensitizer. The goal of this study was to evaluate the effect of PDT using topical ALA on normal guinea pig (g.p.) skin and g.p. skin in which the stratum corneum was removed by being tape-stripped (TS). Evaluation consisted of gross examination, PpIX fluorescence detection, reflectance spectroscopy, and histology. There was no effect from the application of light or ALA alone. Normal non-TS g.p. skin treated with ALA and light was unaffected unless high light and ALA doses were used. Skin from which the stratum corneum was removed was highly sensitive to treatment with ALA and light: 24 h after treatment, the epidermis showed full thickness necrosis, followed by complete repair within 7 d. Time-dependent fluorescence excitation and emission spectra were determined to characterize the chromophore and to demonstrate a build-up of the porphyrin in the skin. These data support the view that PDT with topical ALA is a promising approach for the treatment of epidermal cutaneous disorders." @default.
• W2002246590 created "2016-06-24" @default.
• W2002246590 creator A5014493557 @default.
• W2002246590 creator A5026518632 @default.
• W2002246590 creator A5058184923 @default.
• W2002246590 creator A5065977118 @default.
• W2002246590 date "1992-08-01" @default.
• W2002246590 modified "2023-10-16" @default.
• W2002246590 title "Effects of photodynamic therapy with topical application of 5-aminolevulinic acid on normal skin of hairless guinea pigs" @default.
• W2002246590 cites W1506108633 @default.
• W2002246590 cites W1540769577 @default.
• W2002246590 cites W1975286778 @default.
• W2002246590 cites W2009023255 @default.
• W2002246590 cites W2009538781 @default.
• W2002246590 cites W2009905356 @default.
• W2002246590 cites W2028224679 @default.
• W2002246590 cites W2056217859 @default.
• W2002246590 cites W2059825021 @default.
• W2002246590 cites W2066429867 @default.
• W2002246590 cites W2107601217 @default.
• W2002246590 cites W2118965406 @default.
• W2002246590 cites W2141095211 @default.
• W2002246590 doi "https://doi.org/10.1016/1011-1344(92)85128-h" @default.
• W2002246590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1453276" @default.
• W2002246590 hasPublicationYear "1992" @default.
• W2002246590 type Work @default.
• W2002246590 sameAs 2002246590 @default.
• W2002246590 citedByCount "94" @default.
• W2002246590 countsByYear W20022465902012 @default.
• W2002246590 countsByYear W20022465902014 @default.
• W2002246590 countsByYear W20022465902015 @default.
• W2002246590 countsByYear W20022465902016 @default.
• W2002246590 countsByYear W20022465902017 @default.
• W2002246590 countsByYear W20022465902018 @default.
• W2002246590 countsByYear W20022465902019 @default.
• W2002246590 countsByYear W20022465902020 @default.
• W2002246590 countsByYear W20022465902021 @default.
• W2002246590 countsByYear W20022465902022 @default.
• W2002246590 countsByYear W20022465902023 @default.
• W2002246590 crossrefType "journal-article" @default.
• W2002246590 hasAuthorship W2002246590A5014493557 @default.
• W2002246590 hasAuthorship W2002246590A5026518632 @default.
• W2002246590 hasAuthorship W2002246590A5058184923 @default.
• W2002246590 hasAuthorship W2002246590A5065977118 @default.
• W2002246590 hasConcept C105702510 @default.
• W2002246590 hasConcept C120665830 @default.
• W2002246590 hasConcept C121332964 @default.
• W2002246590 hasConcept C121608353 @default.
• W2002246590 hasConcept C126322002 @default.
• W2002246590 hasConcept C142724271 @default.
• W2002246590 hasConcept C16005928 @default.
• W2002246590 hasConcept C178790620 @default.
• W2002246590 hasConcept C181199279 @default.
• W2002246590 hasConcept C185592680 @default.
• W2002246590 hasConcept C2776217839 @default.
• W2002246590 hasConcept C2776458125 @default.
• W2002246590 hasConcept C2777789703 @default.
• W2002246590 hasConcept C2778370115 @default.
• W2002246590 hasConcept C2778417259 @default.
• W2002246590 hasConcept C2779156968 @default.
• W2002246590 hasConcept C2779480358 @default.
• W2002246590 hasConcept C2779671804 @default.
• W2002246590 hasConcept C2780699678 @default.
• W2002246590 hasConcept C2781323092 @default.
• W2002246590 hasConcept C2781469039 @default.
• W2002246590 hasConcept C55493867 @default.
• W2002246590 hasConcept C71924100 @default.
• W2002246590 hasConcept C75473681 @default.
• W2002246590 hasConcept C91881484 @default.
• W2002246590 hasConceptScore W2002246590C105702510 @default.
• W2002246590 hasConceptScore W2002246590C120665830 @default.
• W2002246590 hasConceptScore W2002246590C121332964 @default.
• W2002246590 hasConceptScore W2002246590C121608353 @default.
• W2002246590 hasConceptScore W2002246590C126322002 @default.
• W2002246590 hasConceptScore W2002246590C142724271 @default.
• W2002246590 hasConceptScore W2002246590C16005928 @default.
• W2002246590 hasConceptScore W2002246590C178790620 @default.
• W2002246590 hasConceptScore W2002246590C181199279 @default.
• W2002246590 hasConceptScore W2002246590C185592680 @default.
• W2002246590 hasConceptScore W2002246590C2776217839 @default.
• W2002246590 hasConceptScore W2002246590C2776458125 @default.
• W2002246590 hasConceptScore W2002246590C2777789703 @default.
• W2002246590 hasConceptScore W2002246590C2778370115 @default.
• W2002246590 hasConceptScore W2002246590C2778417259 @default.
• W2002246590 hasConceptScore W2002246590C2779156968 @default.
• W2002246590 hasConceptScore W2002246590C2779480358 @default.
• W2002246590 hasConceptScore W2002246590C2779671804 @default.
• W2002246590 hasConceptScore W2002246590C2780699678 @default.
• W2002246590 hasConceptScore W2002246590C2781323092 @default.
• W2002246590 hasConceptScore W2002246590C2781469039 @default.
• W2002246590 hasConceptScore W2002246590C55493867 @default.
• W2002246590 hasConceptScore W2002246590C71924100 @default.
• W2002246590 hasConceptScore W2002246590C75473681 @default.
• W2002246590 hasConceptScore W2002246590C91881484 @default.
• W2002246590 hasIssue "3" @default.
• W2002246590 hasLocation W20022465901 @default.
• W2002246590 hasLocation W20022465902 @default.
• W2002246590 hasOpenAccess W2002246590 @default.

• next