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- W2002246876 abstract "Interferon (IFN) treatment induces tyrosine phosphorylation and nuclear translocation of Stat1 (signal transducer and activator of transcription) to activate or repress transcription. We report here that a member of the protein inhibitor of activated STAT family, PIASy, is a transcriptional corepressor of Stat1. IFN treatment triggers the in vivo interaction of Stat1 with PIASy, which represses Stat1-mediated gene activation without blocking the DNA binding activity of Stat1. An LXXLL coregulator signature motif located near the NH(2) terminus of PIASy, although not involved in the PIASy-Stat1 interaction, is required for the transrepression activity of PIASy. Our studies identify PIASy as a transcriptional corepressor of Stat1 and suggest that different PIAS proteins may repress STAT-mediated gene activation through distinct mechanisms." @default.
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- W2002246876 date "2001-03-13" @default.
- W2002246876 modified "2023-10-10" @default.
- W2002246876 title "A transcriptional corepressor of Stat1 with an essential LXXLL signature motif" @default.
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- W2002246876 doi "https://doi.org/10.1073/pnas.051489598" @default.
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