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- W2002247631 abstract "Objective: The authors examined whether motor coordination difficulties assessed in childhood predict later adult schizophrenia spectrum outcomes. Method: A standardized childhood neurological examination was administered to a sample of 265 Danish children in 1972, when participants were 10–13 years old. Adult diagnostic information was available for 244 members of the sample. Participants fell into three groups: children whose mothers or fathers had a psychiatric hospital diagnosis of schizophrenia (N=94); children who had at least one parent with a psychiatric record of hospitalization for a nonpsychotic disorder (N=84); and children with no parental records of psychiatric hospitalization (N=66). Psychiatric outcomes of the offspring were assessed through psychiatric interviews in 1992 when participants were 31–33 years of age, as well as through a scan of national psychiatric registers completed in May 2007. Results: Children who later developed a schizophrenia spectrum disorder (N=32) displayed significantly higher scores on a scale of coordination deficits compared with those who did not develop a mental illness in this category (N=133). Conclusions: Results from this study provide further support for the neurodevelopmental hypothesis of schizophrenia and underscore the potential role of cerebellar and/or basal ganglia abnormalities in the etiology and pathophysiology of schizophrenia." @default.
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- W2002247631 date "2009-09-01" @default.
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- W2002247631 title "Childhood Motor Coordination and Adult Schizophrenia Spectrum Disorders" @default.
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- W2002247631 doi "https://doi.org/10.1176/appi.ajp.2009.08091400" @default.
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