Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002249346> ?p ?o ?g. }
- W2002249346 endingPage "9" @default.
- W2002249346 startingPage "1" @default.
- W2002249346 abstract "The human umbilical cord forms a connection between the placenta and the foetus. It is composed of two arteries and one vein surrounded by Wharton's jelly. Pre-eclampsia is accompanied by extensive remodeling of extracellular matrix of umbilical cord. Matrix metalloproteinases (MMPs) are engaged in degradation of extracellular matrix proteins and activation/inactivation of certain cytokines and enzymes. These enzymes will probably play a central role in the release of matrix-embedded cytokines and growth factors. MMP-2 (gelatinase A) is the main collagenolytic enzyme of both umbilical artery and vein. Other metalloproteinases are present in several times lower amounts. Reduced activity of collagen-degrading enzymes may be a factor, which enhances the accumulation of collagen and some other proteins in the pre-eclamptic umbilical cord tissues. It seems to be possible that similar alterations occur in other fetal blood vessels. It may result in an increase in peripheral resistance as well as an increase in the blood pressure in the fetal vascular system. Some observations suggest that the raised pressure may persist after birth. Pre-eclampsia may be a factor that evokes an initiation of hypertension in utero and its amplification through childhood and adulthood." @default.
- W2002249346 created "2016-06-24" @default.
- W2002249346 creator A5023642363 @default.
- W2002249346 creator A5071707973 @default.
- W2002249346 date "2011-01-01" @default.
- W2002249346 modified "2023-09-25" @default.
- W2002249346 title "Extracellular Matrix Remodeling of the Umbilical Cord in Pre-eclampsia as a Risk Factor for Fetal Hypertension" @default.
- W2002249346 cites W1491678226 @default.
- W2002249346 cites W1571553794 @default.
- W2002249346 cites W1593295279 @default.
- W2002249346 cites W1669342624 @default.
- W2002249346 cites W1924074893 @default.
- W2002249346 cites W1927710162 @default.
- W2002249346 cites W1932296264 @default.
- W2002249346 cites W1939015970 @default.
- W2002249346 cites W1965074521 @default.
- W2002249346 cites W1966205148 @default.
- W2002249346 cites W1971902403 @default.
- W2002249346 cites W1973417313 @default.
- W2002249346 cites W1977013066 @default.
- W2002249346 cites W1977797217 @default.
- W2002249346 cites W1980039229 @default.
- W2002249346 cites W1981688121 @default.
- W2002249346 cites W1986612792 @default.
- W2002249346 cites W1990653503 @default.
- W2002249346 cites W1990804300 @default.
- W2002249346 cites W2004712535 @default.
- W2002249346 cites W2007087277 @default.
- W2002249346 cites W2009217822 @default.
- W2002249346 cites W2009498205 @default.
- W2002249346 cites W2012518099 @default.
- W2002249346 cites W2017185391 @default.
- W2002249346 cites W2017395514 @default.
- W2002249346 cites W2019997266 @default.
- W2002249346 cites W2022323105 @default.
- W2002249346 cites W2030578048 @default.
- W2002249346 cites W2030776545 @default.
- W2002249346 cites W2042416174 @default.
- W2002249346 cites W2043565741 @default.
- W2002249346 cites W2043893304 @default.
- W2002249346 cites W2052565777 @default.
- W2002249346 cites W2057599053 @default.
- W2002249346 cites W2063276829 @default.
- W2002249346 cites W2067561829 @default.
- W2002249346 cites W2071912314 @default.
- W2002249346 cites W2073974662 @default.
- W2002249346 cites W2079959298 @default.
- W2002249346 cites W2080200730 @default.
- W2002249346 cites W2082672977 @default.
- W2002249346 cites W2084130123 @default.
- W2002249346 cites W2084614422 @default.
- W2002249346 cites W2090842150 @default.
- W2002249346 cites W2092276657 @default.
- W2002249346 cites W2098382287 @default.
- W2002249346 cites W2099669152 @default.
- W2002249346 cites W2105602863 @default.
- W2002249346 cites W2112161526 @default.
- W2002249346 cites W2117082569 @default.
- W2002249346 cites W2127553657 @default.
- W2002249346 cites W2150700955 @default.
- W2002249346 cites W2157285450 @default.
- W2002249346 cites W2167027591 @default.
- W2002249346 cites W2167864556 @default.
- W2002249346 doi "https://doi.org/10.1155/2011/542695" @default.
- W2002249346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3065902" @default.
- W2002249346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21490792" @default.
- W2002249346 hasPublicationYear "2011" @default.
- W2002249346 type Work @default.
- W2002249346 sameAs 2002249346 @default.
- W2002249346 citedByCount "19" @default.
- W2002249346 countsByYear W20022493462012 @default.
- W2002249346 countsByYear W20022493462013 @default.
- W2002249346 countsByYear W20022493462014 @default.
- W2002249346 countsByYear W20022493462015 @default.
- W2002249346 countsByYear W20022493462016 @default.
- W2002249346 countsByYear W20022493462017 @default.
- W2002249346 countsByYear W20022493462018 @default.
- W2002249346 countsByYear W20022493462019 @default.
- W2002249346 countsByYear W20022493462020 @default.
- W2002249346 countsByYear W20022493462021 @default.
- W2002249346 countsByYear W20022493462022 @default.
- W2002249346 countsByYear W20022493462023 @default.
- W2002249346 crossrefType "journal-article" @default.
- W2002249346 hasAuthorship W2002249346A5023642363 @default.
- W2002249346 hasAuthorship W2002249346A5071707973 @default.
- W2002249346 hasBestOaLocation W20022493461 @default.
- W2002249346 hasConcept C109523444 @default.
- W2002249346 hasConcept C126322002 @default.
- W2002249346 hasConcept C134018914 @default.
- W2002249346 hasConcept C16685009 @default.
- W2002249346 hasConcept C172680121 @default.
- W2002249346 hasConcept C189165786 @default.
- W2002249346 hasConcept C202751555 @default.
- W2002249346 hasConcept C203014093 @default.
- W2002249346 hasConcept C2776953305 @default.
- W2002249346 hasConcept C2776955114 @default.
- W2002249346 hasConcept C2777411675 @default.
- W2002249346 hasConcept C2778964498 @default.