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• W2002249529 abstract "The biochemical processes underlying opiate addiction are complex, but n -methyl- d -aspartate receptor (NMDAR) dysfunction appears to be one contributing factor. NMDAR antagonists, including MK-801 and memantine, have previously been shown to assuage symptoms stemming from opiate withdrawal. The conantokins are a small family of naturally occurring peptide toxins known to specifically antagonize the NMDAR. In the present study, the effects of wild-type and variant conantokins on the suppression of naloxone-induced jumping in morphine-dependent mice were evaluated. Our results demonstrate that NR2B-selective conantokins, viz ., con-G, con-G[S 16 Y] and con-G[γ 7 K], are potent inhibitors of naloxone-induced jumping at low doses (2–15 nmol/kg) compared with con-T, con-R[1-17], and small-molecule antagonists of the NMDAR, including the NR2B-selective agent, ifenprodil. We conclude that the NR2B-selective conantokins may find utility as neuropharmacological tools for probing NMDAR-related mechanisms of opiate dependence." @default.
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• W2002249529 date "2006-09-01" @default.
• W2002249529 modified "2023-09-24" @default.
• W2002249529 title "Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice" @default.
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• W2002249529 doi "https://doi.org/10.1016/j.neulet.2006.06.040" @default.
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