Matches in SemOpenAlex for { <https://semopenalex.org/work/W2002249679> ?p ?o ?g. }
- W2002249679 endingPage "3813" @default.
- W2002249679 startingPage "3808" @default.
- W2002249679 abstract "Heme is an iron-coordinated porphyrin that is universally essential as a protein cofactor for fundamental cellular processes, such as electron transport in the respiratory chain, oxidative stress response, or redox reactions in various metabolic pathways. Parasitic kinetoplastid flagellates represent a rare example of organisms that depend on oxidative metabolism but are heme auxotrophs. Here, we show that heme is fully dispensable for the survival of Phytomonas serpens , a plant parasite. Seeking to understand the metabolism of this heme-free eukaryote, we searched for heme-containing proteins in its de novo sequenced genome and examined several cellular processes for which heme has so far been considered indispensable. We found that P. serpens lacks most of the known hemoproteins and does not require heme for electron transport in the respiratory chain, protection against oxidative stress, or desaturation of fatty acids. Although heme is still required for the synthesis of ergosterol, its precursor, lanosterol, is instead incorporated into the membranes of P. serpens grown in the absence of heme. In conclusion, P. serpens is a flagellate with unique metabolic adaptations that allow it to bypass all requirements for heme." @default.
- W2002249679 created "2016-06-24" @default.
- W2002249679 creator A5006265708 @default.
- W2002249679 creator A5017195796 @default.
- W2002249679 creator A5022370191 @default.
- W2002249679 creator A5034005898 @default.
- W2002249679 creator A5043143598 @default.
- W2002249679 creator A5044350305 @default.
- W2002249679 creator A5069508892 @default.
- W2002249679 creator A5070093601 @default.
- W2002249679 creator A5086563727 @default.
- W2002249679 date "2012-02-21" @default.
- W2002249679 modified "2023-10-17" @default.
- W2002249679 title "Aerobic kinetoplastid flagellate <i>Phytomonas</i> does not require heme for viability" @default.
- W2002249679 cites W1523886755 @default.
- W2002249679 cites W1762630411 @default.
- W2002249679 cites W1833247211 @default.
- W2002249679 cites W1967086390 @default.
- W2002249679 cites W1967528101 @default.
- W2002249679 cites W1971437832 @default.
- W2002249679 cites W1971956078 @default.
- W2002249679 cites W1976051657 @default.
- W2002249679 cites W1976107241 @default.
- W2002249679 cites W1977648825 @default.
- W2002249679 cites W1985608394 @default.
- W2002249679 cites W1989959009 @default.
- W2002249679 cites W1990053148 @default.
- W2002249679 cites W2000016159 @default.
- W2002249679 cites W2001013371 @default.
- W2002249679 cites W2004189719 @default.
- W2002249679 cites W2006223442 @default.
- W2002249679 cites W2006472852 @default.
- W2002249679 cites W2007167713 @default.
- W2002249679 cites W2012714287 @default.
- W2002249679 cites W2023099428 @default.
- W2002249679 cites W2030750846 @default.
- W2002249679 cites W2033365688 @default.
- W2002249679 cites W2034472876 @default.
- W2002249679 cites W2037264038 @default.
- W2002249679 cites W2037604710 @default.
- W2002249679 cites W2038555200 @default.
- W2002249679 cites W2041231457 @default.
- W2002249679 cites W2045186739 @default.
- W2002249679 cites W2058608211 @default.
- W2002249679 cites W2064909724 @default.
- W2002249679 cites W2068406520 @default.
- W2002249679 cites W2071869086 @default.
- W2002249679 cites W2081027140 @default.
- W2002249679 cites W2081957623 @default.
- W2002249679 cites W2083135851 @default.
- W2002249679 cites W2090025142 @default.
- W2002249679 cites W2097954758 @default.
- W2002249679 cites W2105093529 @default.
- W2002249679 cites W2115898123 @default.
- W2002249679 cites W2116496925 @default.
- W2002249679 cites W2119362018 @default.
- W2002249679 cites W2140012092 @default.
- W2002249679 cites W2144008452 @default.
- W2002249679 cites W2145554441 @default.
- W2002249679 cites W2148738130 @default.
- W2002249679 cites W2151265156 @default.
- W2002249679 cites W2157980713 @default.
- W2002249679 cites W2166973365 @default.
- W2002249679 cites W2168696662 @default.
- W2002249679 cites W2168804389 @default.
- W2002249679 cites W2169435692 @default.
- W2002249679 cites W2171888671 @default.
- W2002249679 cites W2172266455 @default.
- W2002249679 cites W2300552860 @default.
- W2002249679 cites W4256086813 @default.
- W2002249679 cites W947775449 @default.
- W2002249679 doi "https://doi.org/10.1073/pnas.1201089109" @default.
- W2002249679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3309753" @default.
- W2002249679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22355128" @default.
- W2002249679 hasPublicationYear "2012" @default.
- W2002249679 type Work @default.
- W2002249679 sameAs 2002249679 @default.
- W2002249679 citedByCount "56" @default.
- W2002249679 countsByYear W20022496792013 @default.
- W2002249679 countsByYear W20022496792014 @default.
- W2002249679 countsByYear W20022496792015 @default.
- W2002249679 countsByYear W20022496792016 @default.
- W2002249679 countsByYear W20022496792017 @default.
- W2002249679 countsByYear W20022496792018 @default.
- W2002249679 countsByYear W20022496792019 @default.
- W2002249679 countsByYear W20022496792020 @default.
- W2002249679 countsByYear W20022496792021 @default.
- W2002249679 countsByYear W20022496792022 @default.
- W2002249679 crossrefType "journal-article" @default.
- W2002249679 hasAuthorship W2002249679A5006265708 @default.
- W2002249679 hasAuthorship W2002249679A5017195796 @default.
- W2002249679 hasAuthorship W2002249679A5022370191 @default.
- W2002249679 hasAuthorship W2002249679A5034005898 @default.
- W2002249679 hasAuthorship W2002249679A5043143598 @default.
- W2002249679 hasAuthorship W2002249679A5044350305 @default.
- W2002249679 hasAuthorship W2002249679A5069508892 @default.
- W2002249679 hasAuthorship W2002249679A5070093601 @default.
- W2002249679 hasAuthorship W2002249679A5086563727 @default.